The number of opioid prescriptions dispensed to U.S. youth more than doubled over a decade. Over the same period serious opioid-related adverse drug events (ADEs) soared to include thousands of hospital admissions and hundreds of accidental overdose deaths annually. Furthermore, recent estimates suggest that on an average day 2500 adolescents in the U.S. will misuse an opioid for the first time. The staggering number of ADEs and widespread misuse among youth reflects, in large part, a lack of knowledge about the potential dangers of opioids. We and others have previously shown that poor opioid risk understanding leads to risky and potentially dangerous opioid analgesic decision-making including misuse. Thus, transforming the way in which providers give risk information at the time of opioid prescribing is critical to improve the safety of these potent analgesics in the homes of children, adolescents and emerging adults. The overarching goal of our research is to improve opioid analgesic safety and efficacy by optimizing opioid risk recognition, informed analgesic decision-making, and drug storage/disposal behaviors among parents, adolescents and young adults who are prescribed these agents for home use. With this proposal, we aim to demonstrate that our Scenario-Tailored Opioid Messaging Program (STOMP?) will: 1) Improve opioid risk understanding and analgesic decision-making; 2) Enhance analgesic self-efficacy, analgesic use, storage behaviors and pain outcomes, and 3) To demonstrate that the STOMP? plus provision of an efficient method to get rid of left-over medications will effectively nudge participants to safely dispose of left-over opioid analgesics. Parents of children aged 5-17 years, and emerging adults (18-23 years) who are prescribed opioids for acute, short-lived pain after ambulatory or short stay surgery will be randomly assigned to receive our interventions or a routine provider informational interaction at the time of opioid prescribing. We will follow participants for up to 30 days to assess their knowledge, risk perceptions, analgesic-decisions and use, pain outcomes, and drug storage and disposal behaviors. These comprehensive data will allow us to compare the intervention and control groups to identify the most effective and efficient means to optimize opioid-related risk reduction decisions and behaviors while enhancing participants' ability to manage pain. Our innovative research will provide important data to inform providers on how to best improve opioid analgesic risk knowledge that will, in turn, promote safe and effective use of opioid analgesics in the homes of children, adolescents and emerging adults.
Public Health Relevance: Millions of children and adolescents are prescribed opioid pain relievers each year, placing them at risk for serious adverse events and misuse in the home setting. Parents who manage these medicines, therefore, need to recognize opioid-related risks and make decisions that will both reduce these risks yet ensure effective pain relief for their children. The proposed research will evaluate new strategies to help parents learn about opioid risks, make safe and effective analgesic decisions, and develop and demonstrate safe drug management behaviors.
| Voepel-Lewis, Terri; Zikmund-Fisher, Brian J; Boyd, Carol J et al. (2018) Effect of a Scenario-tailored Opioid Messaging Program on Parents' Risk Perceptions and Opioid Decision-making. Clin J Pain 34:497-504 |
| McCabe, Sean Esteban; Wilens, Timothy E; Boyd, Carol J et al. (2018) Age-specific risk of substance use disorders associated with controlled medication use and misuse subtypes in the United States. Addict Behav 90:285-293 |
