We plan to study auditory evoked potentials (AEPs) in both clinical neurological disorders and animal experiments to define neural mechanisms of the generation of these potentials and their application to disordered brain function. In particular, we will study in experimental animals the role of cells and nerve fibers in generating far-field auditory brainstem components using specific lesion methods and in an in-vitro model system using nerve fibers passing between fluid compartments of different volumes and impedances. Long-latency AEPs related to the encoding of words and tones and their subsequent memorization will be studied in normal subjects and patients with focal hemispheric lesions to define neural correlates of language processing and auditory memory. The definition of binaural processes relevant for sound localization will be defined in middle and long-latency AEPs by the occurence of binaural interaction components and related to several psychoacoustic measures in normal subjects, patients with neurological lesions, and in children during maturation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000106-16
Application #
3215704
Study Section
Hearing Research Study Section (HAR)
Project Start
1977-09-01
Project End
1991-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
16
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697