Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC002640-02
Application #
2128101
Study Section
Sensory Disorders and Language Study Section (CMS)
Project Start
1995-06-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wadsworth Center
Department
Type
DUNS #
110521739
City
Menands
State
NY
Country
United States
Zip Code
12204
Sheng, J; Hua, Z; Guo, J et al. (2001) Identification of a new human CYP2A gene fragment with close linkage to CYP2GP1. Drug Metab Dispos 29:4-7
Hines, R N; Luo, Z; Cresteil, T et al. (2001) Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors. Drug Metab Dispos 29:623-33
Sheng, J; Guo, J; Hua, Z et al. (2000) Characterization of human CYP2G genes: widespread loss-of-function mutations and genetic polymorphism. Pharmacogenetics 10:667-78
Gu, J; Su, T; Chen, Y et al. (2000) Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity. Toxicol Appl Pharmacol 165:158-62
Zhang, J; Zhang, Q Y; Guo, J et al. (2000) Identification and functional characterization of a conserved, nuclear factor 1-like element in the proximal promoter region of CYP1A2 gene specifically expressed in the liver and olfactory mucosa. J Biol Chem 275:8895-902
Zhang, Q Y; Ding, X; Dunbar, D et al. (1999) Induction of rat small intestinal cytochrome P-450 2J4. Drug Metab Dispos 27:1123-7
Gu, J; Dudley, C; Su, T et al. (1999) Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosa. Biochem Biophys Res Commun 266:262-7
Zhang, J; Ding, X (1998) Identification and characterization of a novel tissue-specific transcriptional activating element in the 5'-flanking region of the CYP2A3 gene predominantly expressed in rat olfactory mucosa. J Biol Chem 273:23454-62
Hua, Z; Zhang, Q Y; Su, T et al. (1997) cDNA cloning, heterologous expression, and characterization of mouse CYP2G1, an olfactory-specific steroid hydroxylase. Arch Biochem Biophys 340:208-14
Sheng, J; Ding, X (1996) Identification of human genes related to olfactory-specific CYP2G1. Biochem Biophys Res Commun 218:570-4