We propose to continue our investigations of spatial influences on language function and to explore the anatomic and functional bases on these effects. In Part 1, subjects with single hemispheric infarctions are tested on a battery of language tasks in which the location to which they attend is systematically manipulated. Objectives of this component of the investigation are to determine the prevalence of spatial effects on language function and to define the anatomic bases of these effects by correlating performance with lesion site as defined by neuro-imaging studies. In Part 2, those subjects who demonstrate significant spatial effects on this test battery serve as subjects in a second series of studies aimed at defining the mechanisms that underlie these effects. These studies, motivated by our provisional account of spatial effects on cognitive function (the spatial registration hypothesis), will permit us to extend and refine this hypothesis. The proposed investigations have both clinical and theoretical significance. From a theoretical standpoint, these studies should increase our understanding of the role of spatial information in maintaining distributed brain systems in registration, as well as of the brain mechanisms that support this binding function. The potential clinical significance of this work is also clear. If patients with brain injury do indeed demonstrate significant spatial effects in language processing, it may be possible to improve patients' functional capacity simply by controlling the site and/or side to which they attend or act.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
7R01DC002754-06
Application #
6408589
Study Section
Special Emphasis Panel (ZRG1-CMS (02))
Program Officer
Cooper, Judith
Project Start
1995-09-30
Project End
2003-06-30
Budget Start
2000-10-01
Budget End
2001-06-30
Support Year
6
Fiscal Year
2000
Total Cost
$186,336
Indirect Cost
Name
University of Pennsylvania
Department
Neurology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Coslett, H Branch; Lie, Eunhui (2008) Simultanagnosia: Effects of semantic category and repetition blindness. Neuropsychologia 46:1853-63
Lie, Eunhui; Branch Coslett, H (2006) The effect of gaze direction on sound localization in brain-injured and normal adults. Exp Brain Res 168:322-36
Boronat, Consuelo B; Buxbaum, Laurel J; Coslett, H Branch et al. (2005) Distinctions between manipulation and function knowledge of objects: evidence from functional magnetic resonance imaging. Brain Res Cogn Brain Res 23:361-73
Wolk, David A; Coslett, H Branch; Glosser, Guila (2005) The role of sensory-motor information in object recognition: evidence from category-specific visual agnosia. Brain Lang 94:131-46
Wolk, David A; Coslett, H Branch (2004) Hemispheric mediation of spatial attention: pseudoneglect after callosal stroke. Ann Neurol 56:434-6
Saffran, Eleanor M; Coslett, H Branch; Keener, Matthew T (2003) Differences in word associations to pictures and words. Neuropsychologia 41:1541-6
Larson, C R; Burnett, T A; Bauer, J J et al. (2001) Comparison of voice F0 responses to pitch-shift onset and offset conditions. J Acoust Soc Am 110:2845-8
Rajaram, S; Coslett, H B (2000) Acquisition and transfer of new verbal information in amnesia: retrieval and neuroanatomical constraints. Neuropsychology 14:427-55
Coslett, H B (2000) Acquired dyslexia. Semin Neurol 20:419-26
Coslett, H B (1998) Evidence for a disturbance of the body schema in neglect. Brain Cogn 37:527-44