The goal of the proposed investigation is to achieve a better understanding of the molecular pathology of otosclerosis and ultimately develop better forms of treatment and prevention.
The specific aims are to investigate bone metabolism of the otic capsule of normal mice and mice with genetic defects which give rise to otosclerosis in humans. We will apply what we learn from the mouse model to achieve a better understanding of factors which may result in abnormal otic capsule remodeling in humans. To accomplish this we will obtain bone specimens from normal patients and patients with otosclerosis, and study osteoblast bone cells in culture. We will apply what we learn from the mouse studies to normal human otic capsule physiology and determine which molecular factors are important in the initiation of otic capsule remodeling. Specifically, we will study defects in type 1 collagen gene expression and determine what effects these defects have on osteoblast physiology that may lead to the development of otosclerosis. If successful, the proposed study will result in a better understanding of the molecular factors involved in the development of otosclerosis, the development of genetic tests that will allow for identification of individuals who are at risk for developing otosclerosis, and an in vitro method for evaluating potential therapeutic agents.
| Stankovic, Konstantina M; Adachi, Osamu; Tsuji, Kunikazu et al. (2010) Differences in gene expression between the otic capsule and other bones. Hear Res 265:83-9 |
| Stankovic, Konstantina M; Kristiansen, Arthur G; Bizaki, Argyro et al. (2007) Studies of otic capsule morphology and gene expression in the Mov13 mouse--an animal model of type I osteogenesis imperfecta. Audiol Neurootol 12:334-43 |
| McKenna, Michael J; Kristiansen, Arthur G (2007) Molecular biology of otosclerosis. Adv Otorhinolaryngol 65:68-74 |
| Chen, Zhiqiang; Mikulec, Anthony A; McKenna, Michael J et al. (2006) A method for intracochlear drug delivery in the mouse. J Neurosci Methods 150:67-73 |
| Stankovic, Konstantina M; McKenna, Michael J (2006) Current research in otosclerosis. Curr Opin Otolaryngol Head Neck Surg 14:347-51 |
| Zehnder, Andreas F; Kristiansen, Arthur G; Adams, Joe C et al. (2005) Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule. Laryngoscope 115:172-7 |
| Chen, Zhiqiang; Kujawa, Sharon G; McKenna, Michael J et al. (2005) Inner ear drug delivery via a reciprocating perfusion system in the guinea pig. J Control Release 110:1-19 |
| McKenna, Michael J; Nguyen-Huynh, Anh T; Kristiansen, Arthur G (2004) Association of otosclerosis with Sp1 binding site polymorphism in COL1A1 gene: evidence for a shared genetic etiology with osteoporosis. Otol Neurotol 25:447-50 |
| Clayton, Amy E; Mikulec, Anthony A; Mikulec, Katharine H et al. (2004) Association between osteoporosis and otosclerosis in women. J Laryngol Otol 118:617-21 |
| Johns, Donald R; Colby, Kathryn A (2002) Treatment of Leber's hereditary optic neuropathy: theory to practice. Semin Ophthalmol 17:33-8 |
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