The overall objective of the investigators is to apply both classic and new measures of vestibular function to the study of Meniere's disease (MD). These measures would enable earlier diagnosis which, in turn, could lead to better treatment response. These methods have the potential to provide a superior means of monitoring the course of the disease and its response to therapy. Finally, these vestibular function measures may provide new insights into the pathophysiology of MD symptoms since they are based upon the physiology of specific parts of the vestibular end-organs. To accomplish these goals, this project will apply vestibular function tests to three groups of subjects: normal controls, subjects with total unilateral vestibular hypofunction (UVH) after acoustic neuroma removal, and MD subjects who, by the nature of their disease, have partial UVH. The three specific aims of this grant are: 1) Characterize the temporal relationship between acute vertigo attacks and long-term loss of vestibular function in MD subjects by correlating results of serial vestibular test batteries with clinical vestibular symptom status; 2) Test the hypothesis that otolith organ dysfunction is an early and consistent finding in MD by applying two new tests of otolith function, positional optokinetic afternystagmus (pOKAN) and vestibular evoked myogenic potentials (VEMP); and 3) Lay the groundwork for detailed clinicopathological studies of the correlation between vestibular function tests and temporal bone vestibular otopathology by soliciting enrollment of study subjects as future temporal bone donors to the NIDCD National Temporal Bone, Hearing and Balance Pathology Resource Registry.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-IFCN-6 (01))
Program Officer
Platt, Christopher
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts Eye and Ear Infirmary
United States
Zip Code
Lin, Ming-Yee; Timmer, Ferdinand C A; Oriel, Brad S et al. (2006) Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops. Laryngoscope 116:987-92
Timmer, Ferdinand C A; Zhou, Guangwei; Guinan, John J et al. (2006) Vestibular evoked myogenic potential (VEMP) in patients with Meniere's disease with drop attacks. Laryngoscope 116:776-9
Rauch, Steven D; Silveira, M Beatriz; Zhou, Guangwei et al. (2004) Vestibular evoked myogenic potentials versus vestibular test battery in patients with Meniere's disease. Otol Neurotol 25:981-6
Rauch, Steven D; Zhou, Guangwei; Kujawa, Sharon G et al. (2004) Vestibular evoked myogenic potentials show altered tuning in patients with Meniere's disease. Otol Neurotol 25:333-8
Mikulec, Anthony A; McKenna, Michael J; Ramsey, Mitchell J et al. (2004) Superior semicircular canal dehiscence presenting as conductive hearing loss without vertigo. Otol Neurotol 25:121-9