The aim of the proposed research is to assess the sensitivity of the latency of the P1 cortical auditory evoked potential as a marker of the development of the central auditory pathways in hearing impaired children who receive intervention through conventional hearing aids, multichannel cochlear implants, or a combination of the two technologies. In a series of 10 experiments we propose to (1) collect age norms for P1 latency in normal hearing infants and children, (2) assess the relationship between P1 latency, degree of hearing loss and speech perception performance in children with varying degrees of hearing loss, (3) conduct longitudinal assessment of P1 latency in hearing-impaired infants who are provided with amplification as an initial intervention, (4) determine whether electrical stimulation from multichannel cochlear implants produces decreases in P1 latencies that were not seen previously with acoustic amplification and (5) cross-validate electrophysiological measures (P1 latencies) to measures of early communicative behavior in order to determine if P1 latencies are an adequate predictor for the initiation of speech and language development following hearing intervention via hearing aids or cochlear implants. Our goal is to provide clinicians with an objective tool to evaluate whether acoustic amplification for hearing impaired children has provided sufficient stimulation for normal development of the central auditory pathways. If clinicians have such a marker, then they can more confidently make a decision about whether to provide a child with a cochlear implant following an appropriate hearing-aid trial. Using the same marker, clinicians will also be able to monitor the maturation of central auditory pathways once electrical stimulation is initiated. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
1R01DC006257-01A1
Application #
6767423
Study Section
Special Emphasis Panel (ZDC1-SRB-R (43))
Program Officer
Donahue, Amy
Project Start
2004-05-01
Project End
2009-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
1
Fiscal Year
2004
Total Cost
$456,890
Indirect Cost
Name
University of Texas-Dallas
Department
Psychology
Type
Other Domestic Higher Education
DUNS #
800188161
City
Richardson
State
TX
Country
United States
Zip Code
75080
Glick, Hannah; Sharma, Anu (2017) Cross-modal plasticity in developmental and age-related hearing loss: Clinical implications. Hear Res 343:191-201
Sharma, Anu; Glick, Hannah (2016) Cross-Modal Re-Organization in Clinical Populations with Hearing Loss. Brain Sci 6:
Sharma, Anu; Glick, Hannah; Campbell, Julia et al. (2016) Cortical Plasticity and Reorganization in Pediatric Single-sided Deafness Pre- and Postcochlear Implantation: A Case Study. Otol Neurotol 37:e26-34
Sharma, Anu; Cardon, Garrett (2015) Cortical development and neuroplasticity in Auditory Neuropathy Spectrum Disorder. Hear Res 330:221-32
Sharma, Anu; Campbell, Julia; Cardon, Garrett (2015) Developmental and cross-modal plasticity in deafness: evidence from the P1 and N1 event related potentials in cochlear implanted children. Int J Psychophysiol 95:135-44
Sharma, Anu; Glick, Hannah; Deeves, Emily et al. (2015) The P1 biomarker for assessing cortical maturation in pediatric hearing loss: a review. Otorinolaringologia 65:103-114
Campbell, Julia; Sharma, Anu (2014) Cross-modal re-organization in adults with early stage hearing loss. PLoS One 9:e90594
Nash-Kille, Amy; Sharma, Anu (2014) Inter-trial coherence as a marker of cortical phase synchrony in children with sensorineural hearing loss and auditory neuropathy spectrum disorder fitted with hearing aids and cochlear implants. Clin Neurophysiol 125:1459-70
Sharma, Anu; Glick, Hannah; Campbell, Julia et al. (2013) CENTRAL AUDTIORY DEVELOPMENT IN CHILDREN WITH HEARING LOSS: CLINICAL RELEVANCE OF THE P1 CAEP BIOMARKER IN HEARING-IMPAIRED CHILDREN WITH MULTIPLE DISABILITIES. Hearing Balance Commun 11:
Cardon, Garrett; Sharma, Anu (2013) Central auditory maturation and behavioral outcome in children with auditory neuropathy spectrum disorder who use cochlear implants. Int J Audiol 52:577-86

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