A new treatment manipulating intention substrates for language production in """"""""nonfluent"""""""" aphasia patients was developed. The intention component involves initiating word-finding trials with a complex left-hand movement. In a preliminary study, the rate of change in naming accuracy was faster for this treatment than for a similar treatment without the intention component. However, the assumption that the treatment evokes a shift of language production functions from the left to the right frontal lobe has been tested only in a small number of patients (N = 5) whose lateralization was variable before treatment, and appropriate stringent control procedures to verify that the shift in lateralization was due to the intention component were not used. The proposed study will address the hypothesized shift in lateralization in a larger sample of """"""""nonfluent"""""""" aphasia patients and with an appropriate control group. In a parallel group design, 13 patients will receive the intention treatment and 13 patients will receive a control treatment that is identical to the intention except that the intention component is absent. All subjects will participate in functional magnetic resonance imaging (fMRI) scans of word-finding before and after treatment to measure changes in lateralization of lateral frontal and pre-SMA activity. Only patients with a substantial degree of left frontal activity on the pre-treatment scan will participate. The long-term objective is to determine if the intention treatment produces the hypothesized rightward shift in lateral frontal and pre-SMA activity. There are three specific aims: (1) to determine if repetitive initiation of word production with a complex left-hand movement leads to increased right- hemisphere lateralization of pre-SMA and lateral frontal activity and if these changes can be attributed to the intention component of treatment, (2) to determine whether activity in posterior perisylvian cortices that is entrained to right frontal activity shows a greater increase in right-hemisphere lateralization for the intention than for the control group from pre- to post-treatment fMRI, and (3) to determine whether onset of hemodynamic responses (HDRs) in right motor/premotor cortex becomes more closely associated with the temporal onset of participants' spoken responses across treatment for the intention vs the control treatment. The proposed study has the following potential benefits: First, if successful, the treatment can provide a new treatment vehicle for increasing language function and reducing suffering in patients with """"""""nonfluent"""""""" aphasia. Second, the treatment can produce a paradigm shift in the development of aphasia treatment by emphasizing mechanisms for producing desirable changes in the brain mechanisms for language production and by verifying the target changes with fMRI. ? ? ?
| Bohsali, Anastasia A; Triplett, William; Sudhyadhom, Atchar et al. (2015) Broca's area - thalamic connectivity. Brain Lang 141:80-8 |
| Benjamin, Michelle L; Towler, Stephen; Garcia, Amanda et al. (2014) A Behavioral Manipulation Engages Right Frontal Cortex During Aphasia Therapy. Neurorehabil Neural Repair 28:545-53 |
| Altmann, Lori J P; Hazamy, Audrey A; Carvajal, Pamela J et al. (2014) Delayed Stimulus-Specific Improvements in Discourse Following Anomia Treatment Using an Intentional Gesture. J Speech Lang Hear Res 57:439-54 |
| Reilly, Jamie; Harnish, Stacy; Garcia, Amanda et al. (2014) Lesion symptom mapping of manipulable object naming in nonfluent aphasia: can a brain be both embodied and disembodied? Cogn Neuropsychol 31:287-312 |
| Meinzer, Marcus; Beeson, Pélagie M; Cappa, Stefano et al. (2013) Neuroimaging in aphasia treatment research: consensus and practical guidelines for data analysis. Neuroimage 73:215-24 |
| Moore, Anna Bacon; Li, Zhihao; Tyner, Callie E et al. (2013) Bilateral basal ganglia activity in verbal working memory. Brain Lang 125:316-23 |
| Meinzer, Marcus; Seeds, Lauren; Flaisch, Tobias et al. (2012) Impact of changed positive and negative task-related brain activity on word-retrieval in aging. Neurobiol Aging 33:656-69 |
| Meinzer, Marcus; Flaisch, Tobias; Seeds, Lauren et al. (2012) Same modulation but different starting points: performance modulates age differences in inferior frontal cortex activity during word-retrieval. PLoS One 7:e33631 |
| Fitzgerald, David B; Gullett, Joseph M; Levy, Charles E et al. (2011) Delayed diagnosis of intracerebral foreign body from the Vietnam War. Mil Med 176:228-31 |
| Park, Hyejin; Rogalski, Yvonne; Rodriguez, Amy D et al. (2011) Perceptual cues used by listeners to discriminate fluent from nonfluent narrative discourse. Aphasiology 25:998-1015 |
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