GABAergic inhibition shapes the response properties of nearly every neuron in the auditory cortex, either directly (through synaptic inhibition onto th examined neuron) or indirectly (by inhibiting the excitatory cells that synapse onto it). This inhibition is generated by the roughly 20% of cortical neurons that are GABAergic. These neurons fall into multiple classes with distinct anatomical, chemical, and biophysical specializations, enabling intricate and precise modulation of cortical function. A full account of how the different types of inhibitory neurons shape cortical processing of sounds has yet to be generated, but will require A) that we understand the sensory or behavioral conditions in which each type is activated, and B) that we understand how their activation affects information processing in their direct targets and in the network overall. The goal of this proposal is to testin awake mice whether parvalbumin (PV) and somatostatin (SST) neurons, the two most numerous types of cortical inhibitory neuron, contribute differentially to auditory processing, in the context of two main questions about their function: 1) whether their effect is selective to non primary inputs or is similar across all parts of a neuron's receptive field, and 2) to what extent they mediate the effects of acoustic context on neural responses.

Public Health Relevance

Both normal aging and mild hearing loss are associated with profound changes in processing of temporal and spectral context. The associated difficulties with speech comprehension lead to social isolation and significant decreases in quality of life. This work will allow us to relate low-level changes in intracortical inhibition to the high-level changes in perception and behavior observed in aging and disease, which will guide development of clinically useful manipulations to restore lost auditory processing capabilities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC014101-02
Application #
8853850
Study Section
Auditory System Study Section (AUD)
Program Officer
Platt, Christopher
Project Start
2014-06-01
Project End
2019-05-31
Budget Start
2015-06-01
Budget End
2016-05-31
Support Year
2
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Raju, Chandrasekhar S; Spatazza, Julien; Stanco, Amelia et al. (2018) Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Cereb Cortex 28:1946-1958
Hoglen, Nerissa E G; Larimer, Phillip; Phillips, Elizabeth A K et al. (2018) Amplitude modulation coding in awake mice and squirrel monkeys. J Neurophysiol 119:1753-1766
Morrill, Ryan J; Hasenstaub, Andrea R (2018) Visual Information Present in Infragranular Layers of Mouse Auditory Cortex. J Neurosci 38:2854-2862
Phillips, Elizabeth A K; Schreiner, Christoph E; Hasenstaub, Andrea R (2017) Cortical Interneurons Differentially Regulate the Effects of Acoustic Context. Cell Rep 20:771-778
Larimer, Phillip; Spatazza, Julien; Stryker, Michael P et al. (2017) Development and long-term integration of MGE-lineage cortical interneurons in the heterochronic environment. J Neurophysiol 118:131-139
Phillips, Elizabeth A K; Schreiner, Christoph E; Hasenstaub, Andrea R (2017) Diverse effects of stimulus history in waking mouse auditory cortex. J Neurophysiol 118:1376-1393
Phillips, Elizabeth Ak; Hasenstaub, Andrea R (2016) Asymmetric effects of activating and inactivating cortical interneurons. Elife 5:
Larimer, Phillip; Spatazza, Julien; Espinosa, Juan Sebastian et al. (2016) Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity. Cell Rep 16:1391-1404
Seybold, Bryan A; Phillips, Elizabeth A K; Schreiner, Christoph E et al. (2015) Inhibitory Actions Unified by Network Integration. Neuron 87:1181-1192