Resources Facilities The Eaton-Peabody Laboratories (EPL) at the Massachusetts Eye and Ear Infirmary (MEEI) occupies ~10,000 sq ft, 2500 sq ft and 2000 sq ft on floors 4, 6 and 3, respectively. The laboratory is fully equipped for neurophysiological, anatomic, histologic, immunohistochemical and molecular studies. Clinical The Masschusetts Eye and Ear Infirmary is a tertiary referral hospital and a teaching affiliate of Harvard Medical School. The hospital has state of the art facilities for care of patients with hearing loss. Animal There is a fully equipped animal care facility at MEEI, which includes two animal rooms (~400 sq. ft. each) reserved for use by members of EPL. The facility also includes rooms for acute and chronic animals. Computer Personal computers with internet access are available throughout the EPL. Computer facilities are maintained by full time computer programmer and systems analysts. Office The P.I. has a 200 sq ft office at MEEI adjacent to her dedicated laboratory space of ~1000 sq ft. Other The P.I. has access to the viral core facility at Massachusetts Eye and Ear. The core facility is fully equipped for customized viral vector design.
Vestibular schwannoma (VS) is a non-cancerous intracranial tumor that can cause disabling problems, including hearing loss, tinnitus, balance disturbances and facial paralysis. No drug is FDA-approved to treat VS or the associated hearing loss. By studying human VS-secreted molecules that are likely mediators of hearing loss, we pave the way for future targeted therapies with broad relevance for human sensorineural hearing loss.
|Sagers, Jessica E; Brown, Adam S; Vasilijic, Sasa et al. (2018) Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. Sci Rep 8:5437|
|Zhao, Yingchao; Liu, Pinan; Zhang, Na et al. (2018) Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proc Natl Acad Sci U S A 115:E2077-E2084|
|Ren, Yin; Sethi, Rosh K V; Stankovic, Konstantina M (2018) Acute Otitis Media and Associated Complications in United States Emergency Departments. Otol Neurotol 39:1005-1011|
|Landegger, Lukas D; Pan, Bifeng; Askew, Charles et al. (2017) A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nat Biotechnol 35:280-284|
|Sagers, Jessica E; Landegger, Lukas D; Worthington, Steven et al. (2017) Human Cochlear Histopathology Reflects Clinical Signatures of Primary Neural Degeneration. Sci Rep 7:4884|
|?ahin, Mehmet ?lhan; Sagers, Jessica E; Stankovic, Konstantina M (2017) Cochlear Implantation: Vast Unmet Need to Address Deafness Globally. Otol Neurotol 38:786-787|
|Ren, Yin; Sagers, Jessica E; Landegger, Lukas D et al. (2017) Tumor-Penetrating Delivery of siRNA against TNF? to Human Vestibular Schwannomas. Sci Rep 7:12922|
|Landegger, Lukas D; Sagers, Jessica E; Dilwali, Sonam et al. (2017) A Unified Methodological Framework for Vestibular Schwannoma Research. J Vis Exp :|
|Landegger, Lukas D; Lee, Jong D; Linthicum Jr, Fred H et al. (2017) Cochlear Dysfunction is not Common in Human Meningioma of the Internal Auditory Canal. Otol Neurotol 38:e486-e489|
|Landegger, Lukas D; Dilwali, Sonam; Stankovic, Konstantina M (2017) Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research. J Vis Exp :|