Anomia is the inability to access and retrieve the intended words during language production, and is a cardinal feature of the acquired neurogenic language disorder known as aphasia. Aphasia affects approximately 1 million people in the US and, given the aging trend in the population, the incidence of aphasia will increase in the coming decades. Communication difficulties have a significant impact on the health-related quality of life of people with aphasia (PWA), and are associated with substantial healthcare costs. Current methods for diagnosing and characterizing anomia involve confrontation naming tests (CNTs), in which a subject is presented with an image and asked to verbally identify its contents. For example, they might see a drawing of a stethoscope, and would be expected to say the word, ?stethoscope.? A subject with semantic anomia, however, might instead say ?ambulance?? a word that, while incorrect, is semantically related to the target word. A subject with a different kind of anomia, in contrast, might say ?telescope?? a semantically unrelated word, but one that is phonologically related. By presenting several such items, and counting the number and types of errors produced by the subject, a clinician can learn about the type and severity of anomia that the subject is experiencing. CNTs, while clinically valuable, have several problems. They are time-consuming to administer, and to score them, the clinician must make a large number of informed, but subjective, decisions. In this project, we will be developing a computerized system to automate these decisions, which will be useful in two ways. First, it will make it much easier and faster for clinicians to administer these tests, which will save time, and will allow the clinicians to focus on their patients rather than on scoring tests. Second, our automated approach will open the door to many new ways that confrontation naming tests can be used, since they will no longer require an expert clinician to administer them. As one example of this, in the second and third aims of this project, we will be extending our computerized scoring system beyond the CNT context, and into natural language. We will develop algorithms to recognize paraphasias in spoken language samples, and to make the same classifications as to their type as we can make on CNT test items. This will enable clinicians to reliably and objectively analyze their patients' speech, and to screen for and assess their level of anomia.

Public Health Relevance

Patients who have experienced a stroke or other brain injury frequently experience anomia- a condition in which they are unable to produce words when speaking. There are several different ways that clinicians characterize anomia in their patients, but they are very time-consuming to use, and require the clinician to make difficult and subjective judgments. Our goal is to create a computerized system for detecting and characterizing an individual's anomia, which will open the door to new ways of treating anomia and reduce clinical workload.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC015999-02
Application #
9741676
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Cooper, Judith
Project Start
2018-09-01
Project End
2023-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239