It is the purpose of this research project to continue to develop, adapt and apply experimental designs and methods of statistical analysis to dental and oral research. Emphasis will be placed on gingival and periodontal diseases, with attention focused initially on clinical variables and subsequently on microbiological variables. One of the major sets of analyses will be of the correlations that exist between measurements made on different sites within the same mouth. One result would be to help resolve the controversy as to whether the site or the person is the appropriate unit of analysis in experiments in periodontology. Another will be to characterize the heterogeneity that exists within the mouth by applying factor analyses and cluster analyses to site-specific data. The hypothesis will be tested that sites which are statistically similar on clinical variables will also be similar microbiologically. Another set of analyses will be of clinical data collected longitudinally. Methods of survival analysis will be applied to test hypotheses about the factors affecting the progression from gingivitis to periodontitis. The above analyses will be performed on data sets that have either already been provided (by the Boston Veterans Administration Longitudinal Study) or will be provided (by the Periodontal Research Centers at the Forsyth Dental Center, the Medical College of Virginia, and the State University of New York at Buffalo; and by other research centers including Columbia University and the University of Pennsylvania). In addition to data-analytic research, theoretical research on statistical methods applicable in dental studies will continue. Research will be conducted on nonparametric approaches to survival analysis, on group sequential designs for interim analyses of data from clinical trials, and on the effects of outliers on correlational and other multivariate analyses.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE004068-13
Application #
3218965
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1975-03-01
Project End
1990-02-28
Budget Start
1987-03-01
Budget End
1988-02-29
Support Year
13
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Schools of Public Health
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027
Paik, M C (1992) Parametric variance function estimation for nonnormal repeated measurement data. Biometrics 48:19-30
Fleiss, J L; Mann, J; Paik, M et al. (1991) A study of inter- and intra-examiner reliability of pocket depth and attachment level. J Periodontal Res 26:122-8
Fleiss, J L; Kingman, A (1990) Statistical management of data in clinical research. Crit Rev Oral Biol Med 1:55-66
Fleiss, J L; Turgeon, L; Chilton, N W et al. (1990) Statistical properties of some clinical measures of gingivitis and periodontitis. J Periodontol 61:201-5
Fleiss, J L (1989) A critique of recent research on the two-treatment crossover design. Control Clin Trials 10:237-43
Fleiss, J L; Levin, B (1988) Sample size determination in studies with matched pairs. J Clin Epidemiol 41:727-30
Fleiss, J L; Wallenstein, S; Chilton, N W et al. (1988) A re-examination of within-mouth correlations of attachment level and of change in attachment level. J Clin Periodontol 15:411-4
Fleiss, J L; Park, M H; Chilton, N W (1987) Within-mouth correlations and reliabilities for probing depth and attachment level. J Periodontol 58:460-3
Fleiss, J L (1986) Analysis of data from multiclinic trials. Control Clin Trials 7:267-75
Fleiss, J L (1986) Significance tests have a role in epidemiologic research: reactions to A. M. Walker. Am J Public Health 76:559-60

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