The nature of periodontal disease as a localized bacterial infection has led to this investigation of the effects of antibacterial agents locally delivered from devices placed within the periodontal pocket or sulcus. Antibacterial agents are loaded into 0.25 mm O.D. cellulose acetate hollow fibers which are placed into areas where periodontal disease exists. Concentrations achieved locally are several thousand times that possible by systemic administration of the same drug wheras total dosage is reduced by a factor of one hundred or more. Currently, studies are underway to compare the ability of antibacterial agents administered locally to control the disease with conventional therapy. Insofar as effects on numbers of organisms within the periodontal pocket is concerned, it appears that local delivey of tetracycline is comparable to repeat scaling. No side effects or adverse reactions have been observed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE005334-05
Application #
3219360
Study Section
Oral Biology and Medicine Study Section (OBM)
Project Start
1980-03-01
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Forsyth Institute
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
Goodson, J M; Tanner, A (1992) Antibiotic resistance of the subgingival microbiota following local tetracycline therapy. Oral Microbiol Immunol 7:113-7
Heijl, L; Dahlen, G; Sundin, Y et al. (1991) A 4-quadrant comparative study of periodontal treatment using tetracycline-containing drug delivery fibers and scaling. J Clin Periodontol 18:111-6
Goodson, J M; Cugini, M A (1988) Comparative response of mobile teeth following monolithic fiber therapy or scaling. Compend Suppl :S418-23
Tanner, A C; Goodson, J M (1986) Sampling of microorganisms associated with periodontal disease. Oral Microbiol Immunol 1:15-22
Mandell, R L; Tripodi, L S; Savitt, E et al. (1986) The effect of treatment on Actinobacillus actinomycetemcomitans in localized juvenile periodontitis. J Periodontol 57:94-9
Goodson, J M; Hogan, P E; Dunham, S L (1985) Clinical responses following periodontal treatment by local drug delivery. J Periodontol 56:81-7
Goodson, J M; Offenbacher, S; Farr, D H et al. (1985) Periodontal disease treatment by local drug delivery. J Periodontol 56:265-72
Golub, L M; Goodson, J M; Lee, H M et al. (1985) Tetracyclines inhibit tissue collagenases. Effects of ingested low-dose and local delivery systems. J Periodontol 56:93-7