Abstract

This research proposal is an investigation of the local control of alveolar bone metabolism using the precisely timed and localized events of premolar tooth eruption in the dog. In this model system eruption of mandibular premolars is dependent upon the presence of the dental follicle, is independent of the tooth or its development and is characterized by a coordinated resorption of alveolar bone above and formation of bone below the space occupied by the tooth.
The specific aims of this proposal are to study the cellular and molecular methods by which these metabolic events in alveolar bone are controlled by different regions of the dental follicle. These studies will use microsurgical, biochemical and morphological methods to remove parts of the dental follicle before active eruption begins, to trace cell lineage in follicle and bone and to analyze the components of the extracellular matrix of the dental follicle. The significance of the proposed research lies in potential clinical applications to control alveolar bone metabolism, prevent tooth loss and restore bone mass in the mandible and maxilla.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
2R01DE005996-04A1
Application #
3219712
Study Section
Oral Biology and Medicine Study Section (OBM)
Project Start
1981-09-01
Project End
1986-09-19
Budget Start
1985-09-20
Budget End
1986-09-19
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code

  Publications

Volejnikova, S; Laskari, M; Marks Jr, S C et al. (1997) Monocyte recruitment and expression of monocyte chemoattractant protein-1 are developmentally regulated in remodeling bone in the mouse. Am J Pathol 150:1711-21
Marks Jr, S C; Schroeder, H E (1996) Tooth eruption: theories and facts. Anat Rec 245:374-93
Sweet, H O; Marks Jr, S C; MacKay, C A et al. (1996) Dense incisors (din): a new mouse mutation on chromosome 16 affecting tooth eruption and body size. J Hered 87:162-7
Marks Jr, S C; Cielinski, M J; Sundquist, K T (1996) Bone surface morphology reflects local skeletal metabolism. Microsc Res Tech 33:121-7
Marks Jr, S C; Larson, E K; Wise, G E et al. (1995) Collagen metabolism and tooth eruption: the effects of sodium morrhuate infusions on premolar eruption in dogs. Schweiz Monatsschr Zahnmed 105:1029-32
Sundquist, K; Larson, E K; Marks Jr, S C (1995) Altering tooth eruption by blocking bone resorption--the local delivery of bafilomycin A1. Connect Tissue Res 32:159-63
Bidwell, J P; Fey, E G; Marks Jr, S C (1995) Nuclear matrix-intermediate filament proteins of the dental follicle/enamel epithelium and their changes during tooth eruption in dogs. Arch Oral Biol 40:1047-51
Marks Jr, S C (1995) The basic and applied biology of tooth eruption. Connect Tissue Res 32:149-57
Cielinski, M J; Jolie, M; Wise, G E et al. (1995) The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat. Connect Tissue Res 32:165-9
Popoff, S N; Marks Jr, S C (1995) The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development. Bone 17:437-45

Showing the most recent 10 out of 24 publications