The ultimate goal of this research is to develop a nonshrinking, high performance dental resin matrix material.
The specific aims are: (1) to select the most promising alicyclic stereoisomeric spiroorthocarbonates (SOC) monomeric materials that have previously demonstrated expansion during polymerization (the basic monomer structure has been developed on the current NIH project); (2) to chemically modify these selected monomers for optimization of photoinitiated cationic polymerization; (3) to determine the reactive diluents required for optimization of the monomer formulation to form polymer/copolymers as matrix resins; and (4) to evaluate the physicochemical, mechanical, and initial biological characteristics of the new resin matrix formulations. The study has two phases. Phase I involves the utilization of the alicyclic SOCs developed on the present NIH grant. We have been successful in developing alicyclic stereoisomeric spiroorthocarbonates which expand during polymerization. These monomers are fairly well identified but require an optimization of properties through minor modification. The major objectives of phase I are to identify the SOC monomers which polymerize with the maximum volume expansion and to determine the effects of monomer modification on polymerization rate and solubility parameters. Phase II involves the development of an improved resin matrix material. The goals of this phase are to identify the compatibility of the SOCs with selected reactive diluents; to ascertain photoinitiators and sensitizers for their polymerization; and to determine the physicochemical properties of the resultant matrix resins. This proposal has been revised in compliance with suggestions made in the critique of the initial continuation application. We will concentrate on developing matrix resin materials and wait to formulate composites resins until we have completed the present project.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE008450-05
Application #
3222162
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1988-09-01
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Missouri Kansas City
Department
Type
Schools of Dentistry
DUNS #
800772162
City
Kansas City
State
MO
Country
United States
Zip Code
64110
Eick, J D; Kostoryz, E L; Rozzi, S M et al. (2002) In vitro biocompatibility of oxirane/polyol dental composites with promising physical properties. Dent Mater 18:413-21
Harris, C D; Holder, A J; Eick, J D et al. (2000) Semiempirical and ab initio conformational analysis of 2-methylene-8,8-dimethyl-1,4,6,10-tetraoxaspiro[4.5] decane with application of GIAO-SCF methods to NMR spectrum interpretation. J Mol Graph Model 18:567-80
Millich, F; Jeang, L; Eick, J D et al. (1998) Elements of light-cured epoxy-based dental polymer systems. J Dent Res 77:603-8
Eick, J D; Gwinnett, A J; Pashley, D H et al. (1997) Current concepts on adhesion to dentin. Crit Rev Oral Biol Med 8:306-35
Eick, J D; Miller, R G; Robinson, S J et al. (1996) Quantitative analysis of the dentin adhesive interface by Auger spectroscopy. J Dent Res 75:1027-33
Yourtee, D M; Tong, P Y; Rose, L A et al. (1994) The effect of spiroorthocarbonate volume modifier co-monomers on the in vitro toxicology of trial non-shrinking dental epoxy co-polymers. Res Commun Mol Pathol Pharmacol 86:347-60
Eick, J D; Robinson, S J; Byerley, T J et al. (1993) Adhesives and nonshrinking dental resins of the future. Quintessence Int 24:632-40
Eick, J D; Byerley, T J; Chappell, R P et al. (1993) Properties of expanding SOC/epoxy copolymers for dental use in dental composites. Dent Mater 9:123-7
Eick, J D (1992) Smear layer--materials surface. Proc Finn Dent Soc 88 Suppl 1:225-42
Byerley, T J; Eick, J D; Chen, G P et al. (1992) Synthesis and polymerization of new expanding dental monomers. Dent Mater 8:345-50