The long-term objective of this work is to more clearly define associations between clinically relevant orthodontic biomechanical manipulations, the alveolar bone turnover response and clinical outcomes as measured by tooth movement kinetics and root resorption. The focus of this application will be the impact of the timing of orthodontic appliance reactivations on these parameters. Since the timing of orthodontic appliance reactivations on humans is largely done empirically today, such data will have considerable clinical value. Five overlapping specific aims have been developed taking advantage of prior experience with a rat model for orthodontic tipping in response to 40 gram initial appliance activators.
The first aim considers the events following appliance removal; the second is concerned with tandem activations allowing bone turnover to run its course prior to reactivations. In the third, fourth and fifth aims, increasing amounts of overlap between first and second activations will be modeled based on the known bone turnover dynamics.
In aim three, appliances will be reactivated during the first induction period;
aim four will study reactivation during the first resorption wave and aim five during the first formation wave. Multiple comparisons will be made between reactivation groups. Bone turnover will be documented with quantitative histomorphometry and chemical analyses for changes in phosphatase activities and osteocalcin concentrations in sera. Tooth movement will be assessed cephalometrically and root resorption histomorphometrically.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE008659-06
Application #
2130126
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1988-12-01
Project End
1997-08-31
Budget Start
1994-09-01
Budget End
1995-08-31
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Florida
Department
Dentistry
Type
Schools of Dentistry
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Konoo, T; Kim, Y J; Gu, G M et al. (2001) Intermittent force in orthodontic tooth movement. J Dent Res 80:457-60
Gu, G; Lemery, S A; King, G J (1999) Effect of appliance reactivation after decay of initial activation on osteoclasts, tooth movement, and root resorption. Angle Orthod 69:515-22
King, G J; Archer, L; Zhou, D (1998) Later orthodontic appliance reactivation stimulates immediate appearance of osteoclasts and linear tooth movement. Am J Orthod Dentofacial Orthop 114:692-7
Hughes, B; King, G J (1998) Effect of orthodontic appliance reactivation during the period of peak expansion in the osteoclast population. Anat Rec 251:80-6
King, G J; Latta, L; Rutenberg, J et al. (1997) Alveolar bone turnover and tooth movement in male rats after removal of orthodontic appliances. Am J Orthod Dentofacial Orthop 111:266-75
Zhou, D; Hughes, B; King, G J (1997) Histomorphometric and biochemical study of osteoclasts at orthodontic compression sites in the rat during indomethacin inhibition. Arch Oral Biol 42:717-26
Svanberg, G K; King, G J; Gibbs, C H (1995) Occlusal considerations in periodontology. Periodontol 2000 9:106-17
King, G J; Latta, L; Rutenberg, J et al. (1995) Alveolar bone turnover in male rats: site- and age-specific changes. Anat Rec 242:321-8
Dolce, C; Anguita, J; Brinkley, L et al. (1994) Effects of sialoadenectomy and exogenous EGF on molar drift and orthodontic tooth movement in rats. Am J Physiol 266:E731-8
Keeling, S D; King, G J; McCoy, E A et al. (1993) Serum and alveolar bone phosphatase changes reflect bone turnover during orthodontic tooth movement. Am J Orthod Dentofacial Orthop 103:320-6

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