Abstract

A major area of application of three dimensional computed tomography (3DCT) is imaging of the head. 3DCT has an important role in determining the presence and extent of congenital and acquired craniofacial deformities. The objectives of this proposal are to compare the sensitivity and specificity of 3DCT images in the detection and characterization of craniosynostosis with that of planar CT and routine skull x-rays and to specify the role played by observer experience in the interpretation of these image-based diagnoses. Two hundred patients (100 with and 100 without synostoses will be imaged with CT, 3DCT, and plain skull x-rays. Imaging modalities and levels of observer experience will be tested for significant differences with ROC analysis. We hypothesize that 3DCT is significantly better than other imaging systems for the delineation of craniosynostosis and that for 3DCT the importance of observer experience will be significantly less.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE008909-03
Application #
3222724
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1989-04-01
Project End
1992-12-31
Budget Start
1991-04-01
Budget End
1992-12-31
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Pilgram, T K; Vannier, M W; Marsh, J L et al. (1994) Binary nature and radiographic identifiability of craniosynostosis. Invest Radiol 29:890-6
Vannier, M W; Pilgram, T K; Marsh, J L et al. (1994) Craniosynostosis: diagnostic imaging with three-dimensional CT presentation. AJNR Am J Neuroradiol 15:1861-9
Vannier, M W; Brunsden, B S; Hildebolt, C F et al. (1991) Brain surface cortical sulcal lengths: quantification with three-dimensional MR imaging. Radiology 180:479-84
Vannier, M W (1991) Computer applications in radiology. Curr Opin Radiol 3:258-66
Hildebolt, C F; Vannier, M W; Shrout, M K et al. (1991) ROC analysis of observer-response subjective rating data--application to periodontal radiograph assessment. Am J Phys Anthropol 84:351-61
Hildebolt, C F; Vannier, M W; Knapp, R H (1990) Validation study of skull three-dimensional computerized tomography measurements. Am J Phys Anthropol 82:283-94
Vannier, M W; Hildebolt, C F; Marsh, J L et al. (1989) Craniosynostosis: diagnostic value of three-dimensional CT reconstruction. Radiology 173:669-73
Pilgram, T K; Vannier, M W; Hildebolt, C F et al. (1989) Craniosynostosis: image quality, confidence, and correctness in diagnosis. Radiology 173:675-9