Because of the controversy surrounding the use of mercury-containing amalgam as a restorative material, there is a need to develop an inexpensive posterior restorative alternative which can be used in place of dental amalgam without sacrificing benefits to the patient. The overall objective of this research is to identify alloy powder and liquid gallium alloy combinations which produce biocompatible, clinically-relevant materials with the chemical and physical properties needed for a dental restoration.
Specific aims i nclude: a study of reaction kinetics and mechanisms; physical and mechanical property characterization of clinically relevant materials; thermal stability and corrosion behavior of the alloys; and cytotoxicity of the developed alloys. To achieve these aims, the investigators intend to use SEM/XEDA, WDS, XRD, DTA/DSC, and cell culture techniques. The hypothesis to be tested is that a mixed alloy of an experimental powder without noble metals and a gallium-based liquid alloy can have mechanical strengths and other properties at levels similar to or superior to those of leading high-copper amalgams.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE010178-02
Application #
2131146
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1993-08-01
Project End
1996-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Texas A&M Baylor College of Dentistry
Department
Dentistry
Type
Schools of Dentistry
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75246
Miller, B H; Woldu, M; Nakajima, H et al. (1999) Strength and microstructure of gallium alloys. Dent Mater J 18:96-107
Mash, L K; Miller, B H; Nakajima, H et al. (1997) Handling characteristics of a gallium alloy triturated with alcohol. Am J Dent 10:199-202
Horasawa, N; Nakajima, H; Takahashi, S et al. (1997) Behavior of pure gallium in water and various saline solutions. Dent Mater J 16:200-8
Kaga, M; Nakajima, H; Sakai, T et al. (1996) Gallium alloy restorations in primary teeth: a 12-month study. J Am Dent Assoc 127:1195-200
Wataha, J C; Nakajima, H; Hanks, C T et al. (1994) Correlation of cytotoxicity with element release from mercury- and gallium-based dental alloys in vitro. Dent Mater 10:298-303