Rapid Effects of 1-25-OH-2 Vitamin D3 on Osteoblasts

Farach-Carson, Mary C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Dental & Craniofacial Research (NIDCR)
• Type: Research Project (R01)
• Project #: 5R01DE010318-04
• Application #: 2131233
• Study Section: Oral Biology and Medicine Subcommittee 1 (OBM)
• Project Start: 1992-09-01
• Project End: 1997-08-31
• Budget Start: 1995-09-01
• Budget End: 1997-08-31
• Support Year: 4
• Fiscal Year: 1995

Institution

• Name: University of Texas Health Science Center Houston
• Department: Biochemistry
• Type: Schools of Dentistry
• City: Houston
• State: TX
• Country: United States
• Zip Code: 77225

Publications

Farach-Carson, M C; Ridall, A L (1998) Dual 1,25-dihydroxyvitamin D3 signal response pathways in osteoblasts: cross-talk between genomic and membrane-initiated pathways. Am J Kidney Dis 31:729-42

Duncan, R L; Akanbi, K A; Farach-Carson, M C (1998) Calcium signals and calcium channels in osteoblastic cells. Semin Nephrol 18:178-90

Nemere, I; Farach-Carson, M C (1998) Membrane receptors for steroid hormones: a case for specific cell surface binding sites for vitamin D metabolites and estrogens. Biochem Biophys Res Commun 248:443-9

Meszaros, J G; Farach-Carson, M C (1997) Assay of direct effect of 1,25-dihydroxyvitamin D3 on calcium ion influx into cultured osteoblasts. Methods Enzymol 282:236-43

Li, W; Duncan, R L; Karin, N J et al. (1997) 1,25 (OH)2D3 enhances PTH-induced Ca2+ transients in preosteoblasts by activating L-type Ca2+ channels. Am J Physiol 273:E599-605

Norman, A W; Okamura, W H; Hammond, M W et al. (1997) Comparison of 6-s-cis- and 6-s-trans-locked analogs of 1alpha,25-dihydroxyvitamin D3 indicates that the 6-s-cis conformation is preferred for rapid nongenomic biological responses and that neither 6-s-cis- nor 6-s-trans-locked analogs are preferred for ge Mol Endocrinol 11:1518-31

Meszaros, J G; Karin, N J; Akanbi, K et al. (1996) Down-regulation of L-type Ca2+ channel transcript levels by 1,25-dihyroxyvitamin D3. Osteoblastic cells express L-type alpha1C Ca2+ channel isoforms. J Biol Chem 271:32981-5

Meszaros, J G; Karin, N J; Farach-Carson, M C (1996) Voltage-sensitive calcium channels in osteoblasts: mediators of plasma membrane signalling events. Connect Tissue Res 35:107-11

Khoury, R S; Weber, J; Farach-Carson, M C (1995) Vitamin D metabolites modulate osteoblast activity by Ca+2 influx-independent genomic and Ca+2 influx-dependent nongenomic pathways. J Nutr 125:1699S-1703S

Liu, R; Farach-Carson, M C; Karin, N J (1995) Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. Biochem Biophys Res Commun 214:676-84