Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE010992-02
Application #
2132020
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1995-09-30
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Jagels, M A; Daffern, P J; Hugli, T E (2000) C3a and C5a enhance granulocyte adhesion to endothelial and epithelial cell monolayers: epithelial and endothelial priming is required for C3a-induced eosinophil adhesion. Immunopharmacology 46:209-22
Fukuoka, Y; Ember, J A; Hugli, T E (1999) Ligand binding sites on guinea pig C3aR: point and deletion mutations in the large extracellular loop and vicinity. Biochem Biophys Res Commun 263:357-60
Jagels, M A; Daffern, P J; Zuraw, B L et al. (1999) Mechanisms and regulation of polymorphonuclear leukocyte and eosinophil adherence to human airway epithelial cells. Am J Respir Cell Mol Biol 21:418-27
Pfeifer, P H; Kawahara, M S; Hugli, T E (1999) Possible mechanism for in vitro complement activation in blood and plasma samples: futhan/EDTA controls in vitro complement activation. Clin Chem 45:1190-9
Daffern, P J; Jagels, M A; Saad, J J et al. (1999) Upper airway epithelial cells support eosinophil survival in vitro through production of GM-CSF and prostaglandin E2: regulation by glucocorticoids and TNF-alpha. Allergy Asthma Proc 20:243-53
Daffern, P J; Muilenburg, D; Hugli, T E et al. (1999) Association of urinary leukotriene E4 excretion during aspirin challenges with severity of respiratory responses. J Allergy Clin Immunol 104:559-64
Daffern, P J; Jagels, M A; Hugli, T E (1999) Multiple epithelial cell-derived factors enhance neutrophil survival. Regulation by glucocorticoids and tumor necrosis factor-alpha. Am J Respir Cell Mol Biol 21:259-67
Fischer, W H; Jagels, M A; Hugli, T E (1999) Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg). J Immunol 162:453-9
Hetland, G; Pfeifer, P H; Hugli, T E (1998) Processing of C5a by human polymorphonuclear leukocytes. J Leukoc Biol 63:456-62
Carney, D F; Jagels, M A; Hugli, T E et al. (1998) Effect of serine proteinase inhibitors on neutrophil function: alpha-1-proteinase inhibitor, antichymotrypsin, and a recombinant hybrid mutant of antichymotrypsin (LEX032) modulate neutrophil adhesion interactions. J Leukoc Biol 63:75-82

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