Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE011142-03
Application #
2132278
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Medici, Damian; Hay, Elizabeth D; Olsen, Bjorn R (2008) Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. Mol Biol Cell 19:4875-87
Nawshad, Ali; Medici, Damian; Liu, Chang-Chih et al. (2007) TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex. J Cell Sci 120:1646-53
Medici, Damian; Hay, Elizabeth D; Goodenough, Daniel A (2006) Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol Biol Cell 17:1871-9
Hay, Elizabeth D (2005) The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn 233:706-20
LaGamba, Damian; Nawshad, Ali; Hay, Elizabeth D (2005) Microarray analysis of gene expression during epithelial-mesenchymal transformation. Dev Dyn 234:132-42
Nawshad, A; LaGamba, D; Hay, E D (2004) Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT). Arch Oral Biol 49:675-89
Nawshad, Ali; Hay, Elizabeth D (2003) TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J Cell Biol 163:1291-301
Kim, Kwonseop; Lu, Zifan; Hay, Elizabeth D (2002) Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int 26:463-76
Lavrin, I O; McLean, W; Seegmiller, R E et al. (2001) The mechanism of palatal clefting in the Col11a1 mutant mouse. Arch Oral Biol 46:865-9
Sun, D; Baur, S; Hay, E D (2000) Epithelial-mesenchymal transformation is the mechanism for fusion of the craniofacial primordia involved in morphogenesis of the chicken lip. Dev Biol 228:337-49

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