Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
3R01DE011151-02S1
Application #
2132292
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1994-03-01
Project End
1998-02-28
Budget Start
1995-03-01
Budget End
1996-02-29
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Hayashi, Takuma; Faustman, Denise L (2002) Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. Cancer Res 62:24-7
Hayashi, T; Faustman, D L (2001) Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis. J Appl Physiol 91:2804-15
Hayashi, T; Faustman, D (2000) Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis. J Biol Chem 275:5238-47
Hayashi, T; Faustman, D (2000) A role for NF-kappaB and the proteasome in autoimmunity. Arch Immunol Ther Exp (Warsz) 48:353-65
Hayashi, T; Faustman, D (2000) Defective function of the proteasome in autoimmunity: involvement of impaired NF-kappaB activation. Diabetes Technol Ther 2:415-28
Hayashi, T; Faustman, D (1999) NOD mice are defective in proteasome production and activation of NF-kappaB. Mol Cell Biol 19:8646-59
Fu, Y; Yan, G; Shi, L et al. (1998) Antigen processing and autoimmunity. Evaluation of mRNA abundance and function of HLA-linked genes. Ann N Y Acad Sci 842:138-55
Yan, G; Shi, L; Fu, Y et al. (1997) Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between patients and controls. Tissue Antigens 50:576-85
Yan, G; Fu, Y; Faustman, D L (1997) Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. J Immunol 159:3068-80
Shi, L; Yan, G; Fu, Y et al. (1997) Human TAP1 polymorphisms detected by denaturing gradient gel electrophoresis. Tissue Antigens 49:421-6

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