Human herpes virus 8, (HHV-8) has been identified in Kaposis sarcoma (KS) as well as in a variety of other tissues including those from the oral cavity. This proposal seeks to determine 1) the cell types in the oral mucosa that support HHV-8 infection, 2) the dependency of cellular differentiation on viral replication, 3) the association of oral HHV-8 infection with oral KS and oral ulceration, 4) the role of HIV-1 co-infection in enhancement of HHV-8 activity and 5) evaluate saliva as a vehicle of HHV-8 transmission. In-situ hybridization and in-situ PCR techniques will be used to identify the cells harboring HHV-8 and HIV-1 genomes and in the cultures of differentiating epithelial cells. A limited cohort and study will be done on HIV-1 positive patients to determine parameters associated with the development of oral KS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE012176-02
Application #
2749378
Study Section
Special Emphasis Panel (ZDE1-YS (31))
Project Start
1997-09-30
Project End
2000-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of London Eastman Dental Institute
Department
Type
DUNS #
City
London
State
Country
United Kingdom
Zip Code
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