Research conducted on this grant has established periodontal disease as a significant risk factor (P=0.0033) for preterm delivery and low birth weight (PLBW) in humans. Data from a case-control study of 124 mothers demonstrate that pregnant women with generalized periodontitis (i.e. greater than or equal to 60% of sites with 3 or more mm of attachment loss) have an adjusted odds ratio of 7.5 for having a PLBW. the risk of having PLBW as a result of periodontal infection is of greater magnitude than the risk attributable to smoking or alcohol usage. This continuation proposal seeks to reveal new data regarding the attributable risk and molecular basis for this newly observed association. In t his continuation proposal we plan to conduct a perspective study of pregnant women to quantify the added burden of periodontal infection using odds ratios and attributable risk for PLBW, analyzing for possible confounders. We will incorporate periodontal disease variables such as measures of disease extent, severity, microbial specificity and local inflammatory mediator secretion, in addition to traditional risk variables to form new multifactorial risk assessment models for PLBW. We will determine whether periodontal crevicular fluid levels of PGE2 or IL-1beta area associated with preterm delivery, premature rupture of membranes (PROM) or impaired fetal growth. This five year prospective study on over 2500 pregnant women will enable us to confirm the association between periodontal disease and PLBW, controlling for potential obstetric confounders such as age, race, nutrition, bacterial vaginosis, prenatal care and behavioral variables.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
3R01DE012453-03S1
Application #
6081063
Study Section
Special Emphasis Panel (ZRG4 (03))
Project Start
1997-04-01
Project End
2002-02-28
Budget Start
1999-05-21
Budget End
2000-02-29
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Dentistry
Type
Schools of Dentistry
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Arce, R M; Caron, K M; Barros, S P et al. (2012) Toll-like receptor 4 mediates intrauterine growth restriction after systemic Campylobacter rectus infection in mice. Mol Oral Microbiol 27:373-81
Hickman, M Ashley; Boggess, Kim A; Moss, Kevin L et al. (2011) Maternal periodontal disease is associated with oxidative stress during pregnancy. Am J Perinatol 28:247-52
Horton, Amanda L; Boggess, Kim A; Moss, Kevin L et al. (2010) Periodontal disease, oxidative stress, and risk for preeclampsia. J Periodontol 81:199-204
Arce, R M; Diaz, P I; Barros, S P et al. (2010) Characterization of the invasive and inflammatory traits of oral Campylobacter rectus in a murine model of fetoplacental growth restriction and in trophoblast cultures. J Reprod Immunol 84:145-53
Bobetsis, Y A; Barros, S P; Lin, D M et al. (2010) Altered gene expression in murine placentas in an infection-induced intrauterine growth restriction model: a microarray analysis. J Reprod Immunol 85:140-8
Horton, Amanda L; Boggess, Kim A; Moss, Kevin L et al. (2009) Maternal periodontal disease and soluble fms-like tyrosine kinase-1 expression. J Periodontol 80:1506-10
Moss, Kevin L; Serlo, Adam D; Offenbacher, Steven et al. (2008) Third molars and the efficacy of mechanical debridement in reducing pathogen levels in pregnant subjects: a pilot study. J Oral Maxillofac Surg 66:1565-9
Horton, Amanda L; Boggess, Kim A; Moss, Kevin L et al. (2008) Periodontal disease early in pregnancy is associated with maternal systemic inflammation among African American women. J Periodontol 79:1127-32
Picklesimer, Amy H; Jared, Heather L; Moss, Kevin et al. (2008) Racial differences in C-reactive protein levels during normal pregnancy. Am J Obstet Gynecol 199:523.e1-6
Ruma, Michael; Boggess, Kim; Moss, Kevin et al. (2008) Maternal periodontal disease, systemic inflammation, and risk for preeclampsia. Am J Obstet Gynecol 198:389.e1-5

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