Periodontal diseases comprise a group of related microbial-induced chronic inflammatory disorders that destroy the tissue supporting the teeth. The goals of this project are: to accelerate the recovery/restoration of new, healthy periodontal architecture by reducing inflammation;to reduce post-operative pain after periodontal surgery;and to create an unfavorable environment for periodontic bacteria. These goals are achieved using biodegradable (bioresorbable) polymers in which the polymer itself is a controlled-release system: the polymer serves as a temporary barrier that degrades into therapeutically active molecules such as non-steroidal anti-inflammatory drugs (NSAIDs) and concurrently releases admixed antimicrobials. We build upon our previous research with salicylate-based polymers, creating new NSAID-based polymers to simultaneously reduce inflammation, control pain, and eliminate bacteria while providing a biodegradable scaffold for restoring periodontal tissues. As a function of in vivo polymer degradation, we present the following questions: 1. Can NSAIDs be incorporated into a polymer backbone, such that hydrolytic degradation of the polymer directly releases the NSAID? 2. Does the localized release of NSAID promote localized bone growth? 3. Can antimicrobials that are physically admixed within the NSAID-based polymers be released concurrent to the chemically incorporated NSAID? 4. Will the combination of physically admixed antimicrobials and polymer degradation-dependent release of NSAID promote bone growth even further? The overall objective of this proposal is to determine if the local delivery of NSAIDs via degradable polymers will simultaneously reduce inflammation, eliminate bacteria and restore healthy periodontal architecture.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE013207-09
Application #
7632121
Study Section
Special Emphasis Panel (ZRG1-MTE (01))
Program Officer
Lumelsky, Nadya L
Project Start
2000-08-01
Project End
2013-03-31
Budget Start
2009-07-01
Budget End
2013-03-31
Support Year
9
Fiscal Year
2009
Total Cost
$294,880
Indirect Cost
Name
Rutgers University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001912864
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Prudencio, Almudena; Faig, Jonathan J; Song, MinJung et al. (2016) Phenolic Acid-based Poly(anhydride-esters) as Antioxidant Biomaterials. Macromol Biosci 16:214-22
Yu, Weiling; Bien-Aime, Stephan; Mattos, Marcelo et al. (2016) Sustained, localized salicylic acid delivery enhances diabetic bone regeneration via prolonged mitigation of inflammation. J Biomed Mater Res A 104:2595-603
Lee, Yong S; Griffin, Jeremy; Masand, Shirley N et al. (2016) Salicylic acid-based poly(anhydride-ester) nerve guidance conduits: Impact of localized drug release on nerve regeneration. J Biomed Mater Res A 104:975-82
Ouimet, Michelle A; Fogaça, Renata; Snyder, Sabrina S et al. (2015) Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation. Macromol Biosci 15:342-50
Stebbins, N D; Faig, J J; Yu, W et al. (2015) Polyactives: controlled and sustained bioactive release via hydrolytic degradation. Biomater Sci 3:1171-87
Snyder, Sabrina S; Anastasiou, Theodore J; Uhrich, Kathryn E (2015) In Vitro Degradation of an Aromatic Polyanhydride with Enhanced Thermal Properties. Polym Degrad Stab 115:70-76
Stebbins, Nicholas D; Ouimet, Michelle A; Uhrich, Kathryn E (2014) Antibiotic-containing polymers for localized, sustained drug delivery. Adv Drug Deliv Rev 78:77-87
Delgado-Rivera, Roberto; Rosario-Meléndez, Roselin; Yu, Weiling et al. (2014) Biodegradable salicylate-based poly(anhydride-ester) microspheres for controlled insulin delivery. J Biomed Mater Res A 102:2736-42
Rosario-Meléndez, Roselin; Yu, Weiling; Uhrich, Kathryn E (2013) Biodegradable polyesters containing ibuprofen and naproxen as pendant groups. Biomacromolecules 14:3542-8
Ouimet, Michelle A; Griffin, Jeremy; Carbone-Howell, Ashley L et al. (2013) Biodegradable ferulic acid-containing poly(anhydride-ester): degradation products with controlled release and sustained antioxidant activity. Biomacromolecules 14:854-61

Showing the most recent 10 out of 29 publications