This study will analyze the association between periodontal disease and recurrent coronary heart disease (CHD) in individuals who have survived a myocardial infarction (MI). The overall goal is to test the hypothesis that periodontal disease is a significant and independent risk factor for recurrent CHD events. In addition potential mechanisms linking periodontal disease to CHD events will be investigated. At baseline 1,200 participants will undergo a detailed interview and health examination that will include information on lifestyle, sociodemographic, and anthropometric variables and CVD risk factors, and a complete oral health examination including measurement of clinical attachment levels and radiographic assessment of interproximal alveolar crestal height. The two aims are to examine the association between recurrent heart disease and periodontal disease as measured by gingival attachment level and radiographic assessment, and to examine the association between recurrent heart disease and levels of bacterial infection. Participants will be followed prospectively annually for an average of 3 years. The investigators state that the proposed study should provide important new information about the temporal association between periodontal disease and CHD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE013585-04
Application #
6634683
Study Section
Special Emphasis Panel (ZRG1-EDC-1 (03))
Program Officer
Canto, Maria Teresa
Project Start
2000-09-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
4
Fiscal Year
2003
Total Cost
$579,512
Indirect Cost
Name
State University of New York at Buffalo
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Williams, Brent A; Dorn, Joan M; Donahue, Richard P et al. (2009) Vitality and recurrent event risk in acute myocardial infarction survivors. Eur J Cardiovasc Prev Rehabil 16:499-505
Andriankaja, Oelisoa Mireille; Genco, Robert J; Dorn, Joan et al. (2007) Periodontal disease and risk of myocardial infarction: the role of gender and smoking. Eur J Epidemiol 22:699-705
Andriankaja, Oelisoa M; Genco, Robert J; Dorn, Joan et al. (2006) The use of different measurements and definitions of periodontal disease in the study of the association between periodontal disease and risk of myocardial infarction. J Periodontol 77:1067-73