Abnormal facial sensation has a negative impact on patient's oral behaviors and may adversely affect a patient's quality of life if the altered sensation persists. Many patients with abnormal sensations retain some sensory function and do not develop chronic pain, and for those individuals there are no currently evidence-based noninvasive therapies. The goal of this project is to evaluate sensory re-training, a rehabilitative therapy that offers significant potential for patients who experience impaired sensory function regardless of the cause. This behavior therapy approach has been used with substantial clinical success with hand injury patients since the 1970s. Re-training appears to enhance central reorganization of the impulses from an injured sensory nerve to the cerebral cortex so that the altered sensory signals can be interpreted and translated into functionally meaningful motor functions. Sensory re-training will be compared to a placebo jaw-opening exercise in a single blind, randomized two-arm parallel group stratified block clinical trial, using orthognathic surgery patients as subjects. Orthognathic surgery patients offer an uncompromised model for the evaluation of new rehabilitative therapies. These healthy patients, treated to correct dentofacial deformity, present for surgery with no neurosensory impairment, but yet routinely experience substantial alterations in facial sensation following the surgical procedure. The effcts of sensory re-training will be evaluated using three types of outcomes: patient-centered measures to assess the magnitude of the negative effect of altered sensation after surgery and the recovery time needed to reach little or no negative effect; neurosensory behavior measures to assess the patient's ability to learn alternate cues for touch perception and discrimination; and a conventional neurosensory contact threshold measure to assess the actual deficit. Our primary focus will be on the patient's perception of the negative impact of altered sensation on daily life.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
1R01DE013967-01A1
Application #
6395331
Study Section
Special Emphasis Panel (ZDE1-PW (26))
Program Officer
Riddle, Melissa
Project Start
2001-07-15
Project End
2006-05-31
Budget Start
2001-07-15
Budget End
2002-05-31
Support Year
1
Fiscal Year
2001
Total Cost
$345,563
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Dentistry
Type
Schools of Dentistry
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Phillips, C; Essick, G (2011) Inferior alveolar nerve injury following orthognathic surgery: a review of assessment issues. J Oral Rehabil 38:547-54
Phillips, Ceib; Blakey 3rd, George; Essick, Greg K (2011) Sensory retraining: a cognitive behavioral therapy for altered sensation. Atlas Oral Maxillofac Surg Clin North Am 19:109-18
Preisser, J S; Phillips, C; Perin, J et al. (2011) Regression models for patient-reported measures having ordered categories recorded on multiple occasions. Community Dent Oral Epidemiol 39:154-63
Phillips, C; Kim, S H; Tucker, M et al. (2010) Sensory retraining: burden in daily life related to altered sensation after orthognathic surgery, a randomized clinical trial. Orthod Craniofac Res 13:169-78
Essick, G K; Phillips, C; Zuniga, J (2007) Effect of facial sensory re-training on sensory thresholds. J Dent Res 86:571-5
Phillips, Ceib; Essick, Greg; Blakey 3rd, George et al. (2007) Relationship between patients'perceptions of postsurgical sequelae and altered sensations after bilateral sagittal split osteotomy. J Oral Maxillofac Surg 65:597-607
Essick, G K; Phillips, C; Turvey, T A et al. (2007) Facial altered sensation and sensory impairment after orthognathic surgery. Int J Oral Maxillofac Surg 36:577-82
Phillips, Ceib; Essick, Greg; Preisser, John S et al. (2007) Sensory retraining after orthognathic surgery: effect on patients'perception of altered sensation. J Oral Maxillofac Surg 65:1162-73
Phillips, Ceib; Essick, Greg; Zuniga, John et al. (2006) Qualitative descriptors used by patients following orthognathic surgery to portray altered sensation. J Oral Maxillofac Surg 64:1751-60