In 1999, patients in the USA received 85,788,400 composite restorations and the numbers continue to rise. Dental composite restorations represent the most prevalent exposure to biomaterials designed to restore form and function of replaced tissues. As such, further improvements in these widely used materials will have a considerable health care impact. While current materials are generally good, dental composites still suffer from deficiencies that limit their utility and performance. These problems include: relatively low conversion leading to leachable monomer, which along with water uptake, provide a decline in mechanical properties over time;lack of toughness;and most significantly, excessive polymerization shrinkage that causes stress. Shrinkage and stress associated with polymerization mean that intact restored margins can not be achieved reliably. All these problems complicate the placement of restorations and limit their service life. In this project, we address these issues through the inherent versatility of polymeric materials that allows controlled formation of heterogeneous structures. Polymerization-induced phase separation will be used to create nano- to micro-scale heterogeneous polymeric materials with high conversion, improved toughness and notably, with minimal stress development due to a late-stage shrinkage recovery unique to this approach. The research plan provides for development of (i) all-methacrylate resin compositions that form heterogeneous polymers, (ii) controlled formation of heterogeneous interpenetrating polymer networks obtained by simultaneous free radical and cationic photopolymerization processes applied to mixtures of monomers with different reactive functional groups and (iii) introduction of novel surface treatments for reinforcing fillers that provide a complementary additional tailored interface in composite materials based on the phase-separating resins. The proposed program will clearly delineate the effective control parameters that can be used to manipulate the polymerization-induced phase separation process to produce low shrinkage and low stress polymeric materials with improved strength, durability and toughness relative to conventional homogeneous materials. These resulting composite formulations will be suitable as next generation, improved dental restoratives. This research will advance fundamental understanding of complex polymeric systems while providing short- and medium-term clinical benefits with restorative materials.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE014227-09
Application #
8089465
Study Section
Oral, Dental and Craniofacial Sciences Study Section (ODCS)
Program Officer
Drummond, James
Project Start
2001-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2011
Total Cost
$354,680
Indirect Cost
Name
University of Colorado Denver
Department
Dentistry
Type
Schools of Dentistry
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Medel, S; Bosch, P; Grabchev, I et al. (2016) Simultaneous Measurement of Fluorescence, Conversion and Physical/mechanical Properties for Monitoring Bulk and Localized Photopolymerization Reactions in Heterogeneous Systems. RSC Adv 6:41275-41286
Kaastrup, Kaja; Aguirre-Soto, Alan; Wang, Chen et al. (2016) UV-Vis/FT-NIR in situ monitoring of visible-light induced polymerization of PEGDA hydrogels initiated by eosin/triethanolamine/O2. Polym Chem 7:592-602
Aguirre-Soto, Alan; Lim, Chern-Hooi; Hwang, Albert T et al. (2014) Visible-light organic photocatalysis for latent radical-initiated polymerization via 2e?/1H? transfers: initiation with parallels to photosynthesis. J Am Chem Soc 136:7418-27
Szczepanski, Caroline R; Stansbury, Jeffrey W (2014) Stress reduction in phase-separated, cross-linked networks: influence of phase structure and kinetics of reaction. J Appl Polym Sci 131:
Shah, Parag K; Stansbury, Jeffrey W (2014) Role of filler and functional group conversion in the evolution of properties in polymeric dental restoratives. Dent Mater 30:586-93
Abu-elenain, Dalia A; Lewis, Steven H; Stansbury, Jeffrey W (2013) Property evolution during vitrification of dimethacrylate photopolymer networks. Dent Mater 29:1173-81
Stansbury, Jeffrey W (2012) Dimethacrylate network formation and polymer property evolution as determined by the selection of monomers and curing conditions. Dent Mater 28:13-22
Szczepanski, Caroline R; Pfeifer, Carmem S; Stansbury, Jeffrey W (2012) A new approach to network heterogeneity: Polymerization Induced Phase Separation in photo-initiated, free-radical methacrylic systems. Polymer (Guildf) 53:4694-4701
Pfeifer, Carmem S; Wilson, Nicholas D; Shelton, Zachary R et al. (2011) Delayed Gelation Through Chain-Transfer Reactions: Mechanism For Stress Reduction In Methacrylate Networks. Polymer (Guildf) 52:3295-3303
Pfeifer, Carmem S; Shelton, Zachary R; Braga, Roberto R et al. (2011) Characterization of dimethacrylate polymeric networks: a study of the crosslinked structure formed by monomers used in dental composites. Eur Polym J 47:162-170

Showing the most recent 10 out of 16 publications