Skeletal bone loss, in concert with underlying local factors, may create an environment conducive to accelerated loss of oral bone. In the dentate, this may manifest as loss of tooth support. In the edentulous, osteoporosis may augment local anatomic, biologic and mechanical factors resulting in extensive ridge atrophy. Therefore, skeletal bone loss may increase the need for, and influence the outcome of periodontal, pre-prosthetic and implant surgical procedures. Research into this area, however, has been plagued with problems ranging from small sample sizes to the inability to control for confounding variables. We have a unique opportunity to use an existing cohort of men 65 years or older recruited for the Osteoporotic Fractures in Men study (MrOS) - a prospective, multi-center study on the determinants of osteoporosis and fractures in men. This cohort is well characterized for all known variables associated with bone biology and skeletal health and will allow us to carefully evaluate the relationship between skeletal and oral bone loss in a cost-effective manner. It will also give us the opportunity to evaluate the impact of medical, lifestyle, and dietary factors on the prevalence and progression of periodontitis. We are proposing adding a longitudinal study of oral health to MrOS (average follow-up of 2.5 years) in Portland, OR and Birmingham, AL (final n = 1,100). Using techniques similar to the Women's Health Initiative (WHI) Oral Ancillary Study we will evaluate alveolar bone height, mandibular bone density, tooth loss, attachment level, probing depth, residual ridge morphometry, and sex steroids. This study gives us a rare opportunity to evaluate the association between general skeletal health and oral disorders while controlling for all known confounding factors. By using techniques similar to the WHI, we will also have the ability to evaluate gender differences. In addition, the stored serum and DNA available from the MrOS should provide an opportunity to explore genetic and biochemical/endocrine factors that may be important regulators of oral bone biology. Since the MrOS cohort is already established through other funds, this request will provide a very cost-effective means for addressing these important oral health issues.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE014386-02
Application #
6620695
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Program Officer
Shum, Lillian
Project Start
2002-05-01
Project End
2007-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
2
Fiscal Year
2003
Total Cost
$485,220
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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Grubbs, Vanessa; Vittinghoff, Eric; Taylor, George et al. (2016) The association of periodontal disease with kidney function decline: a longitudinal retrospective analysis of the MrOS dental study. Nephrol Dial Transplant 31:466-72
Schulze-Späte, Ulrike; Turner, Ryan; Wang, Ying et al. (2015) Relationship of Bone Metabolism Biomarkers and Periodontal Disease: The Osteoporotic Fractures in Men (MrOS) Study. J Clin Endocrinol Metab 100:2425-33
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Phipps, Kathy R; Chan, Benjamin K S; Jennings-Holt, Marie et al. (2009) Periodontal health of older men: the MrOS dental study. Gerodontology 26:122-9
Orwoll, E S; Chan, B K S; Lambert, L C et al. (2009) Sex steroids, periodontal health, and tooth loss in older men. J Dent Res 88:704-8
Rosca, Elena V; Gillies, Robert J; Caplan, Michael R (2009) Glioblastoma targeting via integrins is concentration dependent. Biotechnol Bioeng 104:408-17
Khosla, Sundeep; Amin, Shreyasee; Orwoll, Eric (2008) Osteoporosis in men. Endocr Rev 29:441-64
Rosca, Elena V; Stukel, Jill M; Gillies, Robert J et al. (2007) Specificity and mobility of biomacromolecular, multivalent constructs for cellular targeting. Biomacromolecules 8:3830-5
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