? This Bioengineering Research Partnership proposal is submitted by a multidisciplinary collaboration of scientists primarily affiliated with the University of California (UC) system. The lead institution is Lawrence Berkeley National Laboratory, with component groups at UC Berkeley and San Francisco campuses. There is also small business collaborator from SkeleTech, Inc., in Bothell, WA. Some of the collaborators have worked together on ceramic projects for over 20 years, while others have worked together on dental research projects for over 10 years. This team has been expanded to include greater expertise in all the disciplines involved in this proposal: materials science, chemistry, biology, and dental/medical science. The research is aimed at development and testing of new implant materials by combining biomimetics with two radically new design philosophies to produce dense and strong bioactive scaffolds that are intended to be partially or completely resorbed and replaced by bone from the host in a sequence resembling bone remodeling. The ultimate goal is to develop strong and tough implant materials for load-bearing applications deriving their strength from nanoparticle hydroxyapatite and their toughness from hydrogel polymers, with the microstructural architecture scale on the order of tens of nanometers and below. Three types of materials will be developed. First, inorganic scaffolds with a dense core and a graded distribution of porosity and surface chemistry will be fabricated by stereolithography and by a novel technology developed in our laboratory based on freeze casting of calcium phosphate suspensions. Second, hydrogels and self-assembling polymers that possess anionic groups and adhesive ligands suitably positioned for the nucleation process and cellular adhesion will be used to direct templatedriven biomimetic mineralization of hydroxyapatite and other biominerals in nanoscopically and microscopically controlled fashion. Third, the resultant porous scaffolds will be used as the matrices to fabricate inorganic-organic composites with improved strength and fracture resistance. This will be achieved by infiltration of the inorganic scaffolds with hydrogels or by direct template-driven biomimetic mineralization of calcium phosphate nanoparticles on the organic scaffolds. Materials that pass the mechanical property tests will be tested in cell cultures and an animal model. Improvement of implants will result in improved health and quality of life for the millions of people who will need implants in the future. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE015633-04
Application #
7067560
Study Section
Special Emphasis Panel (ZRG1-SSS-M (03))
Program Officer
Lumelsky, Nadya L
Project Start
2003-08-04
Project End
2008-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
4
Fiscal Year
2006
Total Cost
$680,814
Indirect Cost
Name
Lawrence Berkeley National Laboratory
Department
Chemistry
Type
Organized Research Units
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720
Jia, Weitao; Lau, Grace Y; Huang, Wenhai et al. (2018) Cellular Response to 3-D Printed Bioactive Silicate and Borosilicate Glass Scaffolds. J Biomed Mater Res B Appl Biomater :
Fu, Qiang; Jia, Weitao; Lau, Grace Y et al. (2018) Strength, toughness, and reliability of a porous glass/biopolymer composite scaffold. J Biomed Mater Res B Appl Biomater 106:1209-1217
Francis, Nicola L; Hunger, Philipp M; Donius, Amalie E et al. (2017) Strategies for neurotrophin-3 and chondroitinase ABC release from freeze-cast chitosan-alginate nerve-guidance scaffolds. J Tissue Eng Regen Med 11:285-294
Moya, José S; Martínez, Arturo; López-Píriz, Roberto et al. (2016) Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs. Sci Rep 6:31478
Jia, Weitao; Lau, Grace Y; Huang, Wenhai et al. (2015) Bioactive Glass for Large Bone Repair. Adv Healthc Mater 4:2842-8
Acevedo, Claire; Bale, Hrishikesh; Gludovatz, Bernd et al. (2015) Alendronate treatment alters bone tissues at multiple structural levels in healthy canine cortical bone. Bone 81:352-363
Bai, Hao; Wang, Dong; Delattre, Benjamin et al. (2015) Biomimetic gradient scaffold from ice-templating for self-seeding of cells with capillary effect. Acta Biomater 20:113-119
Wang, Jianglin; Yang, Mingying; Zhu, Ye et al. (2014) Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds. Adv Mater 26:4961-4966
Snyder, Jessica E; Hunger, Philipp M; Wang, Chengyang et al. (2014) Combined multi-nozzle deposition and freeze casting process to superimpose two porous networks for hierarchical three-dimensional microenvironment. Biofabrication 6:015007
Amugongo, Sarah K; Yao, Wei; Jia, Junjing et al. (2014) Effect of sequential treatments with alendronate, parathyroid hormone (1-34) and raloxifene on cortical bone mass and strength in ovariectomized rats. Bone 67:257-68

Showing the most recent 10 out of 66 publications