Ceramics are widely used in dental and orthopedic applications because of their esthetic value and chemical inertness. However, ceramics are vulnerable to fracture which accounts for millions of dollars annually in replacement costs and can cause significant patient discomfort and loss of productive lifestyle. Despite improvements in material properties, the performance of all-ceramic restorations still fails to match the 'gold standard'of metal-ceramic restorations. Our previous investigations have established relations between failure modes and restoration thickness, surface conditions, ceramic properties, and loading conditions. These findings indicate that monolithic glass-ceramic and veneered-alumina restorations are vulnerable to both occlusal sliding-contact damage and cementation bulk fracture, while the veneered zirconia restorations are prone to veneer chipping and delamination. These findings are consistent with clinical reports. Recent advances in theoretical and experimental work from our current NIDCR-supported project have demonstrated that veneer failure and bulk fracture may be substantially mitigated by controlled compositional gradients within the restoration layer. Such graded structures exhibit significantly higher resistance to sliding- contact damage and flexural bulk fracture relative to their homogeneous counterparts. In this competing renewal application we propose to elucidate enhanced resistance to chipping, veneer/core delamination, and mouth-motion fatigue of graded glass-zirconia materials with and without a thin veneer (0.3 mm) in both flat model structures and anatomically-correct geometries. This will bring us closer to a solution of a clinical problem-chipping, delamination, and fracture of ceramic restorations. Additionally, we propose to establish a simple but powerful edge-indentation technique to assess the toughness properties of graded laminates, a problem area that lies beyond the scope of current fracture testing protocols. We propose to achieve these objectives through three specific aims: 1. Quantify increased resistance to edge-chipping of graded zirconia structures using a novel edge-indentation technique;2. Elucidate crack-interface interaction of graded zirconia structures using a novel crack growth technique and a conventional shear bond test;and 3. Determine resistance to fatigue damage of anatomically-correct glass/zirconia/glass graded structures with or without a thin porcelain veneer relative to commercial veneered and monolithic zirconia systems using a mouth-motion simulator in wet environments. Knowledge generated from this investigation will facilitate the development of smart glass-zirconia graded structures for next-generation dental and orthopedic prostheses with improved damage-tolerance, esthetics, and cementation properties. These improvements will lead to reduced morbidity of dental prostheses and cost of replacement to the public.

Public Health Relevance

This competing renewal proposal aims to develop glass-zirconia graded structures for next-generation all- ceramic dental restorations with improved resistance to chipping, delamination and flexural fracture, as well as improved cementation properties and esthetics. These goals will be accomplished via refinements in graded structure fabrication, novel testing methods, and materials characterization. Knowledge generated from the study will open up new avenues for applications of functionally graded materials in health care, reduce morbidity and costs of dental restoration replacements, improve public health and quality of life, and increase the potential for Public-Private Partnerships to sustain economic growth.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Research Project (R01)
Project #
Application #
Study Section
Oral, Dental and Craniofacial Sciences Study Section (ODCS)
Program Officer
Drummond, James
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
Schools of Dentistry
New York
United States
Zip Code
Chai, Herzl; Mieleszko, Adam J; Chu, Stephen J et al. (2018) Using glass-graded zirconia to increase delamination growth resistance in porcelain/zirconia dental structures. Dent Mater 34:e8-e14
Mao, L; Kaizer, M R; Zhao, M et al. (2018) Graded Ultra-Translucent Zirconia (5Y-PSZ) for Strength and Functionalities. J Dent Res 97:1222-1228
Han, Aifang; Tsoi, James K H; Matinlinna, Jukka P et al. (2018) Effects of different sterilization methods on surface characteristics and biofilm formation on zirconia in vitro. Dent Mater 34:272-281
Kim, Jeongho; Dhital, Sukirti; Zhivago, Paul et al. (2018) Viscoelastic finite element analysis of residual stresses in porcelain-veneered zirconia dental crowns. J Mech Behav Biomed Mater 82:202-209
Zhang, Y; Lawn, B R (2018) Novel Zirconia Materials in Dentistry. J Dent Res 97:140-147
Zhao, M; Sun, Y; Zhang, J et al. (2018) Novel Translucent and Strong Submicron Alumina Ceramics for Dental Restorations. J Dent Res 97:289-295
Fabris, Douglas; Souza, JĂșlio C M; Silva, Filipe S et al. (2017) THERMAL RESIDUAL STRESSES IN BILAYERED, TRILAYERED AND GRADED DENTAL CERAMICS. Ceram Int 43:3670-3678
Zhang, Yu; Kelly, J Robert (2017) Dental Ceramics for Restoration and Metal Veneering. Dent Clin North Am 61:797-819
Alao, Abdur-Rasheed; Stoll, Richard; Song, Xiao-Fei et al. (2017) Fracture, roughness and phase transformation in CAD/CAM milling and subsequent surface treatments of lithium metasilicate/disilicate glass-ceramics. J Mech Behav Biomed Mater 74:251-260
Chai, Herzl; Lawn, Brian R (2017) Fracture resistance of molar teeth with mesial-occlusal-distal (MOD) restorations. Dent Mater 33:e283-e289

Showing the most recent 10 out of 68 publications