The pathogenesis of myofascial face pain (MFP), the most prevalent type of temporomandibular disorder (TMD), remains controversial. One of the key controversiesconcerns the role of sleep bruxism (SB);While relatively weak measures of SB have supported a role of SB in at least some MFP patients, nolaboratory- based sleep study has been undertaken to resolvethis issue definitively. This application proposesas its main aim the conduct of the definitive study of SB in MFP maintenance, in which the separate role of grinding and clenching would be examined. We would also explore the relationship between SB andstress- induced bruxism, as well as the role of genetic anomaliesin modulating the risk of pain among thosewith SB.
A second aim would evaluate the role of central sensitization (CS) in the maintenanceof MFP. Evidence supporting a role for CS in MFP has been limited by biases in the sampling of both patientsand anatomic sites. Therefore, we would examine the role of CS in MFP in a more representative sample of MFP patients and controls, as well as conduct an evaluationof CS in both extratrigeminal and trigeminal regions. Differences in CS in these two areas might suggest different pain maintenance mechanisms. Data collected in the service of these two aims then allows the achievement a third aim, understanding the relationships between SB and CS in MFP, including the possibility that elevations in SB and CS may define subgroupsin which different pain maintenance mechanisms are operative.
These aims can be achieved in the context of a case-control study of 120 MFP patients and 60 demographically-matchedcontrols. Pursuit of these aims will provide firm evidence regarding the role of SB in MFP and will advance understanding of the relationship between SB and CS. This understanding is expectedto support our long-term goal of improving clinical treatment of MFP by targeting treatment to underlying pain-maintenenance mechanisms.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
3R01DE018569-04S1
Application #
7905417
Study Section
Special Emphasis Panel (ZDE1-YL (41))
Program Officer
Kusiak, John W
Project Start
2007-09-01
Project End
2012-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
4
Fiscal Year
2009
Total Cost
$83,160
Indirect Cost
Name
New York University
Department
Dentistry
Type
Schools of Dentistry
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012
Dubrovsky, B; Janal, M N; Lavigne, G J et al. (2017) Depressive symptoms account for differences between self-reported versus polysomnographic assessment of sleep quality in women with myofascial TMD. J Oral Rehabil 44:925-933
Muzalev, Konstantin; Lobbezoo, Frank; Janal, Malvin N et al. (2017) Interepisode Sleep Bruxism Intervals and Myofascial Face Pain. Sleep 40:
Raphael, K G; Santiago, V; Lobbezoo, F (2016) Is bruxism a disorder or a behaviour? Rethinking the international consensus on defining and grading of bruxism. J Oral Rehabil 43:791-8
Raphael, K G; Santiago, V; Lobbezoo, F (2016) Bruxism is a continuously distributed behaviour, but disorder decisions are dichotomous (Response to letter by Manfredini, De Laat, Winocur, & Ahlberg (2016)). J Oral Rehabil 43:802-3
Janal, Malvin N; Raphael, Karen G; Cook, Dane B et al. (2016) Thermal temporal summation and decay of after-sensations in temporomandibular myofascial pain patients with and without comorbid fibromyalgia. J Pain Res 9:641-52
Raphael, K G; Janal, M N; Sirois, D A et al. (2015) Validity of self-reported sleep bruxism among myofascial temporomandibular disorder patients and controls. J Oral Rehabil 42:751-8
Dubrovsky, Boris; Raphael, Karen G; Lavigne, Gilles J et al. (2014) Polysomnographic investigation of sleep and respiratory parameters in women with temporomandibular pain disorders. J Clin Sleep Med 10:195-201
Raphael, K G; Janal, M N; Sirois, D A et al. (2013) Masticatory muscle sleep background electromyographic activity is elevated in myofascial temporomandibular disorder patients. J Oral Rehabil 40:883-91
Raphael, Karen G; Sirois, David A; Janal, Malvin N et al. (2012) Sleep bruxism and myofascial temporomandibular disorders: a laboratory-based polysomnographic investigation. J Am Dent Assoc 143:1223-31
Raphael, Karen G; Janal, Malvin N; Anathan, Sowmya et al. (2009) Temporal summation of heat pain in temporomandibular disorder patients. J Orofac Pain 23:54-64

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