Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK010339-31
Application #
2136662
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1976-04-01
Project End
1999-03-31
Budget Start
1996-04-15
Budget End
1997-03-31
Support Year
31
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Biochemistry
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Newcomb, Martin; Lansakara-P, Dharmika S P; Kim, Hye-Yeong et al. (2007) Products from enzyme-catalyzed oxidations of norcarenes. J Org Chem 72:1128-33
Newcomb, Martin; Chandrasena, R Esala P; Lansakara-P, Dharmika S P et al. (2007) Desaturase reactions complicate the use of norcarane as a mechanistic probe. Unraveling the mixture of twenty-plus products formed in enzyme-catalyzed oxidations of norcarane. J Org Chem 72:1121-7
Vatsis, Kostas P; Coon, Minor J (2005) Oxidative aldehyde deformylation catalyzed by NADPH-cytochrome P450 reductase and the flavoprotein domain of neuronal nitric oxide synthase. Biochem Biophys Res Commun 337:1107-11
Vatsis, Kostas P; Peng, Hwei-Ming; Coon, Minor J (2005) Abolition of oxygenase function, retention of NADPH oxidase activity, and emergence of peroxidase activity upon replacement of the axial cysteine-436 ligand by histidine in cytochrome P450 2B4. Arch Biochem Biophys 434:128-38
Chandrasena, R Esala P; Vatsis, Kostas P; Coon, Minor J et al. (2004) Hydroxylation by the hydroperoxy-iron species in cytochrome P450 enzymes. J Am Chem Soc 126:115-26
Newcomb, Martin; Aebisher, David; Shen, Runnan et al. (2003) Kinetic isotope effects implicate two electrophilic oxidants in cytochrome p450-catalyzed hydroxylations. J Am Chem Soc 125:6064-5
Newcomb, Martin; Hollenberg, Paul F; Coon, Minor J (2003) Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations. Arch Biochem Biophys 409:72-9
Vatsis, Kostas P; Peng, Hwei-Ming; Coon, Minor J (2002) Replacement of active-site cysteine-436 by serine converts cytochrome P450 2B4 into an NADPH oxidase with negligible monooxygenase activity. J Inorg Biochem 91:542-53
Newcomb, Martin; Shen, Runnan; Lu, Yun et al. (2002) Evaluation of norcarane as a probe for radicals in cytochome p450- and soluble methane monooxygenase-catalyzed hydroxylation reactions. J Am Chem Soc 124:6879-86
Vatsis, Kostas P; Coon, Minor J (2002) Ipso-substitution by cytochrome P450 with conversion of p-hydroxybenzene derivatives to hydroquinone: evidence for hydroperoxo-iron as the active oxygen species. Arch Biochem Biophys 397:119-29

Showing the most recent 10 out of 56 publications