Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK011043-26
Application #
2136671
Study Section
Endocrinology Study Section (END)
Project Start
1978-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
26
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Dunn, J T; Dunn, A D (1999) The importance of thyroglobulin structure for thyroid hormone biosynthesis. Biochimie 81:505-9
Colzani, R M; Alex, S; Dunn, A D et al. (1999) The oral administration of human thyroglobulin does not affect the incidence of lymphocytic thyroiditis in the biobreeding Worcester rat. Thyroid 9:831-5
Dunn, A D; Corsi, C M; Myers, H E et al. (1998) Tyrosine 130 is an important outer ring donor for thyroxine formation in thyroglobulin. J Biol Chem 273:25223-9
Dunn, A D; Myers, H E; Dunn, J T (1996) The combined action of two thyroidal proteases releases T4 from the dominant hormone-forming site of thyroglobulin. Endocrinology 137:3279-85
Mason, M E; Struyk, B P; Dunn, J T (1996) mRNA encoding human thyroglobulin's C-terminus is heterogeneous. Thyroid 6:633-7
Mason, M E; Dunn, A D; Wortsman, J et al. (1995) Thyroids from siblings with Pendred's syndrome contain thyroglobulin messenger ribonucleic acid variants. J Clin Endocrinol Metab 80:497-503
Dunn, A D; Crutchfield, H E; Dunn, J T (1991) Proteolytic processing of thyroglobulin by extracts of thyroid lysosomes. Endocrinology 128:3073-80
Dunn, A D; Crutchfield, H E; Dunn, J T (1991) Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L. J Biol Chem 266:20198-204
Lamas, L; Anderson, P C; Fox, J W et al. (1989) Consensus sequences for early iodination and hormonogenesis in human thyroglobulin. J Biol Chem 264:13541-5
Roe, M T; Anderson, P C; Dunn, A D et al. (1989) The hormonogenic sites of turtle thyroglobulin and their homology with those of mammals. Endocrinology 124:1327-32

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