We propose to continue investigations of the biosynthesis and biological function of ferritin protein made on the rough endoplasmic reticulum of cells such as rat hepatocytes or rat hepatoma cells. We also propose to continue investigations of isoferritin protein synthesis by rat hepatocytes and Kupffer cells in vitro, and to begin investigations of the relation of ferritin protein synthesis by intestinal epithelial cells to states of iron overload and iron deficiency in isolated loops of intestine, in vivo and in vitro. In these investigations biochemical and immunochemical methods will be used in conjunction with electron microscopy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK012381-22
Application #
3224856
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1978-01-01
Project End
1991-05-31
Budget Start
1989-06-01
Budget End
1991-05-31
Support Year
22
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
School of Medicine & Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627