Regulation of Phosphorylase Kinase

Walsh, Donal A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK013613-27
• Application #: 2136802
• Study Section: Biochemistry Study Section (BIO)
• Project Start: 1977-07-01
• Project End: 1998-03-31
• Budget Start: 1996-04-01
• Budget End: 1998-03-31
• Support Year: 27
• Fiscal Year: 1996

Institution

• Name: University of California Davis
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 094878337
• City: Davis
• State: CA
• Country: United States
• Zip Code: 95618

Publications

Zhao, J; Hoye, E; Boylan, S et al. (1998) Quaternary structures of a catalytic subunit-regulatory subunit dimeric complex and the holoenzyme of the cAMP-dependent protein kinase by neutron contrast variation. J Biol Chem 273:30448-59

Zhao, J; Trewhella, J; Corbin, J et al. (1997) Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle X-ray scattering in solution. J Biol Chem 272:31929-36

Cawley, K C; Akita, C G; Angelos, K L et al. (1993) Characterization of the gene for rat phosphorylase kinase catalytic subunit. J Biol Chem 268:1194-200

Newsholme, P; Walsh, D A (1992) A kinetic re-interpretation of the regulation of rabbit skeletal-muscle phosphorylase kinase activity by Ca2+ and phosphorylation. Biochem J 283 ( Pt 3):845-8

Lee, J H; Maeda, S; Angelos, K L et al. (1992) Analysis by mutagenesis of the ATP binding site of the gamma subunit of skeletal muscle phosphorylase kinase expressed using a baculovirus system. Biochemistry 31:10616-25

Newsholme, P; Angelos, K L; Walsh, D A (1992) High and intermediate affinity calmodulin binding domains of the alpha and beta subunits of phosphorylase kinase and their potential role in phosphorylation-dependent activation of the holoenzyme. J Biol Chem 267:810-8

Henderson, S J; Newsholme, P; Heidorn, D B et al. (1992) Solution structure of phosphorylase kinase studied using small-angle X-ray and neutron scattering. Biochemistry 31:437-42

Cawley, K C; Akita, C G; Wineinger, M A et al. (1992) Coordinated expression of phosphorylase kinase subunits in regenerating skeletal muscle. J Biol Chem 267:17287-95

Walsh, D A; Newsholme, P; Cawley, K C et al. (1991) Motifs of protein phosphorylation and mechanisms of reversible covalent regulation. Physiol Rev 71:285-304

Cawley, K C; Akita, C G; Walsh, D A (1989) Expression of a cDNA for the catalytic subunit of skeletal-muscle phosphorylase kinase in transfected 3T3 cells. Biochem J 263:223-9