The objectives of this proposal are the synthesis and evauation of novel selective inhibitors of steroid-transforming enzymes. Some of these steroid analogs are designed as active site-directed irreversible inhibitors of 3beta-and (3 and 17) beta-hydroxysteroid dehydrogenases as well as processes involved in the oxidative degradation of lanosterol and of cholesterol. Others are intended to be reversible inhibitors of these enzymes. The mechanisms by which enzyme inhibitiion occurs will be studied. These inhibitors may be of value not only in studies of enzyme action but as potential therapeutic agents in hormone-dependent diseases and in hypercholesterolemic states.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK015918-15
Application #
3225489
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1976-01-01
Project End
1990-03-31
Budget Start
1988-04-01
Budget End
1989-03-31
Support Year
15
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218