Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK016746-24
Application #
2137042
Study Section
Metabolism Study Section (MET)
Project Start
1976-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
24
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Kim, Yeawon; Lee, Heedoo; Manson, Scott R et al. (2016) Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases. J Am Soc Nephrol 27:2974-2982
Kanekura, Kohsuke; Ma, Xiucui; Murphy, John T et al. (2015) IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions. Sci Signal 8:ra62
Hara, Takashi; Mahadevan, Jana; Kanekura, Kohsuke et al. (2014) Calcium efflux from the endoplasmic reticulum leads to ?-cell death. Endocrinology 155:758-68
Urano, Fumihiko (2014) Wolfram syndrome iPS cells: the first human cell model of endoplasmic reticulum disease. Diabetes 63:844-6
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Kanekura, Kohsuke; Ishigaki, Shinsuke; Merksamer, Philip I et al. (2013) Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Lab Invest 93:1254-8
Karzon, Roanne K; Hullar, Timothy E (2013) Audiologic and vestibular findings in Wolfram syndrome. Ear Hear 34:809-12
Jung, Dae Young; Chalasani, Umadevi; Pan, Ning et al. (2013) KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. PLoS One 8:e77851
Bonnycastle, Lori L; Chines, Peter S; Hara, Takashi et al. (2013) Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation. Diabetes 62:3943-50
Oslowski, Christine M; Hara, Takashi; O'Sullivan-Murphy, Bryan et al. (2012) Thioredoxin-interacting protein mediates ER stress-induced ? cell death through initiation of the inflammasome. Cell Metab 16:265-73

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