The long range goal of this research project is to better understand the regulatory events controlling somatostatin biosynthesis. This should provide us with a more complete picture of the molecular events underlining diseases such as diabetes mellitus. This proposal will specifically examine the regulation of somatostatin gene expression using the tools of biochemistry and molecular biology. Somatostatin was originally isolated from the hypothalamus on the basis of its ability to regulate growth hormone secretions from the pituitary gland. Subsequently, it was shown to inhibit both insulin and glucagon release from the pancreas. This hormone also appears to play an important regulatory role in controlling the secretory processes in the gut, kidney, exocrine pancreas, thyroid gland and central nervous system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK018024-12
Application #
3225906
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1979-06-01
Project End
1988-05-31
Budget Start
1987-06-01
Budget End
1988-05-31
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
Earth Sciences/Resources
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
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