This research is concerned with mechanisms of opioid modulation of behavior during development. I propose to investigate a number of phenomena that we have discovered during our most recent finding period. They are: (1) The palliation of stress and pain, through opioid mediation, by sweet and other palatable solutions. (2) The interactions between opioid systems and cholecystokinin as they influence distress reactions. (3) The implications of delayed tolerance in rats on opioid-mediated behaviors. (4) The contribution of opioids to the formation of mother-infant bonds and (5) The development of a model for assessing how maternal chocoholism during pregnancy and lactation influence, behavior of suckling rata before and after the onset of tolerance mechanisms. This last aim arises from findings obtained in our research of human infants. Together, the proposed studies will reveal and explore the characteristics of different interactions between opioid, behavioral, and physiological processes during ontogeny.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK018560-13
Application #
3226084
Study Section
Biopsychology Study Section (BPO)
Project Start
1978-06-01
Project End
1990-05-31
Budget Start
1987-06-20
Budget End
1988-05-31
Support Year
13
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Arts and Sciences
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Blass, E M; Cramer, C P; Fanselow, M S (1993) The development of morphine-induced antinociception in neonatal rats: a comparison of forepaw, hindpaw, and tail retraction from a thermal stimulus. Pharmacol Biochem Behav 44:643-9
Shide, D J; Blass, E M (1991) Opioid mediation of odor preferences induced by sugar and fat in 6-day-old rats. Physiol Behav 50:961-6
Weller, A; Blass, E M (1990) Cholecystokinin conditioning in rats: ontogenetic determinants. Behav Neurosci 104:199-206
Blass, E M; Fillion, T J; Weller, A et al. (1990) Separation of opioid from nonopioid mediation of affect in neonatal rats: nonopioid mechanisms mediate maternal contact influences. Behav Neurosci 104:625-36
Shide, D J; Blass, E M (1989) Opioidlike effects of intraoral infusions of corn oil and polycose on stress reactions in 10-day-old rats. Behav Neurosci 103:1168-75
Kehoe, P; Blass, E M (1989) Conditioned opioid release in ten-day-old rats. Behav Neurosci 103:423-8
Weller, A; Blass, E M (1988) Behavioral evidence for cholecystokinin-opiate interactions in neonatal rats. Am J Physiol 255:R901-7
Blass, E M; Fitzgerald, E (1988) Milk-induced analgesia and comforting in 10-day-old rats: opioid mediation. Pharmacol Biochem Behav 29:9-13