Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK019655-19
Application #
2137360
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1977-04-01
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Picower Institute for Medical Research
Department
Type
DUNS #
City
Manhasset
State
NY
Country
United States
Zip Code
11030
Al-Abed, Y; Bucala, R (2000) Structure of a synthetic glucose derived advanced glycation end product that is immunologically cross-reactive with its naturally occurring counterparts. Bioconjug Chem 11:39-45
Al-Abed, Y; Mitsuhashi, T; Li, H et al. (1999) Inhibition of advanced glycation endproduct formation by acetaldehyde: role in the cardioprotective effect of ethanol. Proc Natl Acad Sci U S A 96:2385-90
Fishbane, S; Bucala, R; Pereira, B J et al. (1997) Reduction of plasma apolipoprotein-B by effective removal of circulating glycation derivatives in uremia. Kidney Int 52:1645-50
Al-Abed, Y; Bucala, R (1997) Efficient scavenging of fatty acid oxidation products by aminoguanidine. Chem Res Toxicol 10:875-9
Pushkarsky, T; Rourke, L; Spiegel, L A et al. (1997) Molecular characterization of a mouse genomic element mobilized by advanced glycation endproduct modified-DNA (AGE-DNA). Mol Med 3:740-9
Wolffenbuttel, B H; Giordano, D; Founds, H W et al. (1996) Long-term assessment of glucose control by haemoglobin-AGE measurement. Lancet 347:513-5
Al-Abed, Y; Liebich, H; Voelter, W et al. (1996) Hydroxyalkenal formation induced by advanced glycosylation of low density lipoprotein. J Biol Chem 271:2892-6
Bucala, R; Vlassara, H (1995) Advanced glycosylation end products in diabetic renal and vascular disease. Am J Kidney Dis 26:875-88
Zimmerman, G A; Meistrell 3rd, M; Bloom, O et al. (1995) Neurotoxicity of advanced glycation endproducts during focal stroke and neuroprotective effects of aminoguanidine. Proc Natl Acad Sci U S A 92:3744-8
Bucala, R; Mitchell, R; Arnold, K et al. (1995) Identification of the major site of apolipoprotein B modification by advanced glycosylation end products blocking uptake by the low density lipoprotein receptor. J Biol Chem 270:10828-32

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