Regulation of N-3 and N-6 Fatty Acid Metabolism

Sprecher, Howard W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK020387-18
• Application #: 2137451
• Study Section: Metabolism Study Section (MET)
• Project Start: 1977-07-01
• Project End: 1997-03-31
• Budget Start: 1995-04-01
• Budget End: 1997-03-31
• Support Year: 18
• Fiscal Year: 1995

Institution

• Name: Ohio State University
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 098987217
• City: Columbus
• State: OH
• Country: United States
• Zip Code: 43210

Publications

Sprecher, H (2000) Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim Biophys Acta 1486:219-31

Mohammed, B S; Luthria, D L; Bakousheva, S P et al. (1997) Regulation of the biosynthesis of 4,7,10,13,16-docosapentaenoic acid. Biochem J 326 ( Pt 2):425-30

Luthria, D L; Sprecher, H (1997) Studies to determine if rat liver contains multiple chain elongating enzymes. Biochim Biophys Acta 1346:221-30

Sprecher, H (1996) New advances in fatty-acid biosynthesis. Nutrition 12:S5-7

Luthria, D L; Mohammed, B S; Sprecher, H (1996) Regulation of the biosynthesis of 4,7,10,13,16,19-docosahexaenoic acid. J Biol Chem 271:16020-5

Luthria, D L; Baykousheva, S P; Sprecher, H (1995) Double bond removal from odd-numbered carbons during peroxisomal beta-oxidation of arachidonic acid requires both 2,4-dienoyl-CoA reductase and delta 3,5,delta 2,4-dienoyl-CoA isomerase. J Biol Chem 270:13771-6

Sprecher, H; Luthria, D L; Mohammed, B S et al. (1995) Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J Lipid Res 36:2471-7

Mohammed, B S; Sankarappa, S; Geiger, M et al. (1995) Reevaluation of the pathway for the metabolism of 7,10,13, 16-docosatetraenoic acid to 4,7,10,13,16-docosapentaenoic acid in rat liver. Arch Biochem Biophys 317:179-84

Nada, M A; Chace, D H; Sprecher, H et al. (1995) Investigation of beta-oxidation intermediates in normal and MCAD-deficient human fibroblasts using tandem mass spectrometry. Biochem Mol Med 54:59-66

Baykousheva, S P; Luthria, D L; Sprecher, H (1995) Peroxisomal-microsomal communication in unsaturated fatty acid metabolism. FEBS Lett 367:198-200