The nuclear matrix of the mammalian nucleus has been isolated and characterized. This cellular structural component appears to be involved in the nuclear functions such as DNA synthesis. The nuclear matrix of the immature rat uterus has high affinity, saturable estrogen binding sites which appears to account for a considerable portion of the salt resistant nuclear estrogen receptors reported by others. The nuclear matrix of the uterus and prostate will be characterized and studied for their binding properties with sex steroid and antisteroid compounds. The nuclear matrix may be associated with a residual structural component extending throughout the cell and is termed the cell matrix. Steroid binding to these components will also be examined.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK022000-16
Application #
3227179
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1978-09-01
Project End
1988-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
16
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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