Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK025687-21
Application #
2137770
Study Section
Immunobiology Study Section (IMB)
Project Start
1979-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1997-11-30
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Harrison, D E; Zhong, R K; Jordan, C T et al. (1997) Relative to adult marrow, fetal liver repopulates nearly five times more effectively long-term than short-term. Exp Hematol 25:293-7
Zhong, R K; Astle, C M; Harrison, D E (1996) Distinct developmental patterns of short-term and long-term functioning lymphoid and myeloid precursors defined by competitive limiting dilution analysis in vivo. J Immunol 157:138-45
Zhong, R K; Donnenberg, A D; Edison, L et al. (1996) The appearance of Thy-1- donor T cells in the peripheral circulation 3-6 weeks after bone marrow transplantation suggests an extrathymic origin. Int Immunol 8:171-6
Jordan, C T; Astle, C M; Zawadzki, J et al. (1995) Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation. Exp Hematol 23:1011-5
Harrison, D E; Zsebo, K M; Astle, C M (1994) Splenic primitive hematopoietic stem cell (PHSC) activity is enhanced by steel factor because of PHSC proliferation. Blood 83:3146-51
Gardner, R V; Lerner, C; Astle, C M et al. (1993) Assessing permanent damage to primitive hematopoietic stem cells after chemotherapy using the competitive repopulation assay. Cancer Chemother Pharmacol 32:450-4
Harrison, D E; Jordan, C T; Zhong, R K et al. (1993) Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations. Exp Hematol 21:206-19
Harrison, D E; Zhong, R K (1992) The same exhaustible multilineage precursor produces both myeloid and lymphoid cells as early as 3-4 weeks after marrow transplantation. Proc Natl Acad Sci U S A 89:10134-8
Harrison, D E (1992) Evaluating functional abilities of primitive hematopoietic stem cell populations. Curr Top Microbiol Immunol 177:13-30
Harrison, D E; Lerner, C P (1991) Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil. Blood 78:1237-40

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