Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK026206-10S1
Application #
3227770
Study Section
Biochemistry Study Section (BIO)
Project Start
1979-04-01
Project End
1993-03-31
Budget Start
1989-07-01
Budget End
1990-03-31
Support Year
10
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33101
Lu, Xiaoqing; Tan, Cheng-Keat; Zhou, Jin-Qiu et al. (2002) Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta. J Biol Chem 277:24340-5
Meyer, Peter R; Matsuura, Suzanne E; Tolun, Adviye A et al. (2002) Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 46:1540-5
Carastro, L Michael; Tan, Cheng-Keat; Selg, Manuel et al. (2002) Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta. Nucleic Acids Res 30:2232-43
He, H; Tan, C K; Downey, K M et al. (2001) A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. Proc Natl Acad Sci U S A 98:11979-84
Meyer, P R; Matsuura, S E; Schinazi, R F et al. (2000) Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates. Antimicrob Agents Chemother 44:3465-72
Meyer, P R; Matsuura, S E; Mian, A M et al. (1999) A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase. Mol Cell 4:35-43
Mozzherin, D J; Tan, C K; Downey, K M et al. (1999) Architecture of the active DNA polymerase delta.proliferating cell nuclear antigen.template-primer complex. J Biol Chem 274:19862-7
Zaika, A; Mozzherin, D J; Tan, C K et al. (1999) A two-dimensional support for selective binding of polyhistidine-tagged proteins: identification of a proliferating cell nuclear antigen point mutant with altered function in vitro. Anal Biochem 268:193-200
Kramata, P; Downey, K M (1999) 9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis. Mol Pharmacol 56:1262-70
Terashima, I; Suzuki, N; Dasaradhi, L et al. (1998) Translesional synthesis on DNA templates containing an estrogen quinone-derived adduct: N2-(2-hydroxyestron-6-yl)-2'-deoxyguanosine and N6-(2-hydroxyestron-6-yl)-2'-deoxyadenosine. Biochemistry 37:13807-15

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