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Huether, Robert; Liu, Zhi-Jie; Xu, Hao et al. (2010) Sequence fingerprint and structural analysis of the SCOR enzyme A3DFK9 from Clostridium thermocellum. Proteins 78:603-13
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Huether, Robert; Mao, Qilong; Duax, William L et al. (2010) The short-chain oxidoreductase Q9HYA2 from Pseudomonas aeruginosa PAO1 contains an atypical catalytic center. Protein Sci 19:1097-103
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Duax, William L; Huether, Robert; Pletnev, Vladimir et al. (2009) Divergent evolution of a Rossmann fold and identification of its oldest surviving ancestor. Int J Bioinform Res Appl 5:280-94
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Thomas, James L; Huether, Robert; Mack, Vance L et al. (2007) Structure/function of human type 1 3beta-hydroxysteroid dehydrogenase: An intrasubunit disulfide bond in the Rossmann-fold domain and a Cys residue in the active site are critical for substrate and coenzyme utilization. J Steroid Biochem Mol Biol 107:80-7
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Mao, Qilong; Duax, William L; Umland, Timothy C (2007) Crystallization and X-ray diffraction analysis of the beta-ketoacyl-acyl carrier protein reductase FabG from Aquifex aeolicus VF5. Acta Crystallogr Sect F Struct Biol Cryst Commun 63:106-9
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Pletnev, Vladimir Z; Thomas, James L; Rhaney, Felicia L et al. (2006) Rational proteomics V: structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3beta-hydroxysteroid dehydrogenase/isomerase type 1. J Steroid Biochem Mol Biol 101:50-60
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Sundlov, Jesse A; Garringer, Julie A; Carney, Jill M et al. (2006) Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli. Acta Crystallogr D Biol Crystallogr 62:734-40
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Duax, William L; Thomas, James; Pletnev, Vladimir et al. (2005) Determining structure and function of steroid dehydrogenase enzymes by sequence analysis, homology modeling, and rational mutational analysis. Ann N Y Acad Sci 1061:135-48
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Thomas, James L; Boswell, Elizabeth L; Scaccia, Launa A et al. (2005) Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. J Biol Chem 280:21321-8
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Duax, William L; Huether, Robert; Pletnev, Vladimir Z et al. (2005) Rational genomics I: antisense open reading frames and codon bias in short-chain oxido reductase enzymes and the evolution of the genetic code. Proteins 61:900-6
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