Abstract

Breast milk contains hormones of peptide character, but very little is known about their role in suckling neonates. The importance of this question is stressed by the fact that many of these hormones are not detectable in infant feeding formulas. The purpose of the present application is to evaluate (using suckling and weanling rats as the experimental mode) gastrointestinal processing of epidermal growth factor and prolactin, the routes of absorption (portal blood vs absorption via lymphatics), as well as delivery and metabolism of orally-absorbed epidermal growth factor and prolactin in selected target organs (i.e., brain, liver lung, skin). The role of the presence of epidermal growth factor and prolactin in milk will be tested further by following development of the gastrointestinal tract and other organs of sucklings by feeding formulas containing known amounts of epidermal growth factor and/or absorption. Finally, the cytoprotective role of epidermal growth factor and prolactin will be tested in an experimental model of necrotizing enterocolitis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK027624-11
Application #
3228397
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1980-01-01
Project End
1992-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
11
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Shinohara, H; Williams, C; Koldovsky, O (1995) The use of poly R-478 as a marker to determine gastric emptying and intestinal propulsive motility in suckling rats. Physiol Res 44:281-6
Kong, W Y; Koldovsky, O; Rao, R K (1992) Appearance of exogenous epidermal growth factor in liver, bile, and intestinal lumen of suckling rats. Gastroenterology 102:661-7
Samulitis-dos Santos, B K; Goda, T; Koldovskyyy, O (1992) Dietary-induced increases of disaccharidase activities in rat jejunum. Br J Nutr 67:267-78
Grimes, J; Schaudies, P; Davis, D et al. (1992) Effect of short-term fasting/refeeding on epidermal growth factor content in the gastrointestinal tract of suckling rats. Proc Soc Exp Biol Med 199:75-80
Pollack, P F; Koldovskyyy, O; Nishioka, K (1992) Polyamines in human and rat milk and in infant formulas. Am J Clin Nutr 56:371-5
Koldovsky, O; Bedrick, A; Rao, R (1991) Role of milk-borne prostaglandins and epidermal growth factor for the suckling mammal. J Am Coll Nutr 10:17-23
Rao, R K (1991) Biologically active peptides in the gastrointestinal lumen. Life Sci 48:1685-704
Jiang, Q; Koldovsky, O; Bedrick, A et al. (1991) Bombesin differentially affects gastric emptying in suckling, weanling and adult rats. J Pharmacol Exp Ther 257:603-7
Rao, R K; Koldovsky, O; Grimes, J et al. (1991) Regional differences in gastrointestinal processing and absorption of epidermal growth factor in suckling rats. Am J Physiol 261:G790-8
Koldovsky, O; Britton, J; Grimes, J et al. (1991) Milk-borne epidermal growth factor (EGF) and its processing in developing gastrointestinal tract. Endocr Regul 25:58-62

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