Enzymatic sulfation of bile acids allows an alternate method of removing these potentially toxic compounds in situations where bile flow is impaired.
The aim of this research is to characterize the enzymes which catalyse the formation of bile acid sulfates, purify them and study the events which control enzyme activity. Antibodies to individual enzymes will be produced in monoclonal culture and used to facilitate the purification and biochemical characterization of each enyzme protein.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK028111-08
Application #
3228587
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1980-12-01
Project End
1990-06-30
Budget Start
1988-07-01
Budget End
1990-06-30
Support Year
8
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Stevens, R D; Lack, L; Collins, R H et al. (1989) Effects of monosulfate esters of taurochenodeoxycholate on bile flow and biliary lipids in hamsters. J Lipid Res 30:673-9