Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK028143-15
Application #
2138094
Study Section
Metabolism Study Section (MET)
Project Start
1981-01-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
15
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Smith, R M; Harada, S; Smith, J A et al. (1998) Insulin-induced protein tyrosine phosphorylation cascade and signalling molecules are localized in a caveolin-enriched cell membrane domain. Cell Signal 10:355-62
Smith, R M; Zhang, S; White, M F et al. (1996) The role of receptor kinase activity and the NPEY960 motif in insulin-accelerated receptor-mediated insulin internalization. J Recept Signal Transduct Res 16:339-55
Harada, S; Smith, R M; Smith, J A et al. (1996) Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation. J Biol Chem 271:30222-6
Harada, S; Smith, R M; Hu, D Q et al. (1996) Dexamethasone inhibits insulin binding to insulin-degrading enzyme and cytosolic insulin-binding protein p82. Biochem Biophys Res Commun 218:154-8
Lee, Y H; Harada, S; Smith, R M et al. (1996) The expression of and insulin binding to cellular thyroid hormone binding protein, but not insulin degrading enzyme, is increased during 3T3-L1 adipocytes differentiation. Biochem Biophys Res Commun 222:839-43
Shah, N; Zhang, S; Harada, S et al. (1995) Electron microscopic visualization of insulin translocation into the cytoplasm and nuclei of intact H35 hepatoma cells using covalently linked Nanogold-insulin. Endocrinology 136:2825-35
Harada, S; Smith, R M; Smith, J A et al. (1995) Insulin-induced egr-1 expression in Chinese hamster ovary cells is insulin receptor and insulin receptor substrate-1 phosphorylation-independent. Evidence of an alternative signal transduction pathway. J Biol Chem 270:26632-8
Harada, S; Smith, R M; Smith, J A et al. (1995) Demonstration of specific insulin binding to cytosolic proteins in H35 hepatoma cells, rat liver and skeletal muscle. Biochem J 306 ( Pt 1):21-8
Shi, C Z; Dhir, R N; Kesavan, P et al. (1995) Mouse embryonic stem cells express receptors of the insulin family of growth factors. Mol Reprod Dev 42:173-9
Bao, S; Smith, R M; Jarett, L et al. (1995) The effects of brefeldin A on the glucose transport system in rat adipocytes. Implications regarding the intracellular locus of insulin-sensitive Glut4. J Biol Chem 270:30199-204

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