Abstract

Neurotensin (NT), released from the intestine by ingestion of fat, slows gastric emptying, stimulates pancreatic secretion, and enhances the uptake of fatty acids. The primary goal of the present application is to study the mechanisms by which NT promotes bile acid output and to understand the nature of the feedback loops which control NT synthesis and secretion. Studies will involve determining the mechanisms of action of NT; that is, whether its effects on increasing bile acid output are secondary to an increase in hepatic synthesis of bile acid and/or involve increased intestinal uptake. In addition, studies to investigate the feedback effects of bile acid on NT receptor expression are planned. Additional studies will determine the effects of the NT antagonist SR48692 on enterohepatic fat function and fat absorption.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK028565-16
Application #
2545697
Study Section
Endocrinology Study Section (END)
Project Start
1980-09-01
Project End
2000-09-29
Budget Start
1997-09-30
Budget End
1998-09-29
Support Year
16
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Physiology
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655

  Publications

Gui, X; Carraway, R E; Dobner, P R (2004) Endogenous neurotensin facilitates visceral nociception and is required for stress-induced antinociception in mice and rats. Neuroscience 126:1023-32
Gui, Xianyong; Carraway, Robert E (2004) Involvement of mast cells in basal and neurotensin-induced intestinal absorption of taurocholate in rats. Am J Physiol Gastrointest Liver Physiol 287:G408-16
Gui, X; Dobner, P R; Carraway, R E (2001) Endogenous neurotensin facilitates enterohepatic bile acid circulation by enhancing intestinal uptake in rats. Am J Physiol Gastrointest Liver Physiol 281:G1413-22
Gui, X; Carraway, R E (2001) Enhancement of jejunal absorption of conjugated bile acid by neurotensin in rats. Gastroenterology 120:151-60
Carraway, R E; Mitra, S P; Cochrane, D E (2000) Pro-xenopsin(s) in vesicles of mammalian brain, liver, stomach and intestine is apparently released into blood and cerebral spinal fluid. Regul Pept 95:115-24
Gui, X; Degolier, T F; Duke, G E et al. (2000) Neurotensin elevates hepatic bile acid secretion in chickens by a mechanism requiring an intact enterohepatic circulation. Comp Biochem Physiol C Toxicol Pharmacol 127:61-70
Mitra, S P; Carraway, R E (1999) Synergistic effects of neurotensin and beta-adrenergic agonist on 3,5-cyclic adenosine monophosphate accumulation and DNA synthesis in prostate cancer PC3 cells. Biochem Pharmacol 57:1391-7
Castagliuolo, I; Wang, C C; Valenick, L et al. (1999) Neurotensin is a proinflammatory neuropeptide in colonic inflammation. J Clin Invest 103:843-9
DeGolier, T F; Place, A R; Duke, G E et al. (1999) Neurotensin modulates the composition of pancreatic exocrine secretions in chickens. J Exp Zool 283:455-62
Feldberg, R S; Cochrane, D E; Carraway, R E et al. (1998) Evidence for a neurotensin receptor in rat serosal mast cells. Inflamm Res 47:245-50

Showing the most recent 10 out of 28 publications